The Reticuloendothelial System and Atherosclerosis

1. Front Matter

   Pages i-xii

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2. Methodology

   1. Application of a Mathematical Model to the Study of RES Phagocytosis in Mice

      • Richard K. Fred, Moris L. Shore

      Pages 1-17

   2. The Use of Radioiodinated Latex Particles for in Vivo Studies of Phagocytosis

      • J. M. Singer, S. Lavie, L. Adlersberg, E. Ende, E. M. Hoenig, Y. Tchorsh

      Pages 18-24

   3. Interaction of Charged Colloids with the RES

      • David J. Wilkins

      Pages 25-33

   4. The Potential Use of Glutaraldehyde-Fixed Liver Cells in the Study of Hepatic Reticuloendothelial and Parenchymal Cell Metabolism

      • N. Baker, M. Cohen

      Pages 34-45

   5. The Function of the Reticuloendothelial System Studied with Isolated Perfused Rat Livers

      • H. Schimassek, J. Helms

      Pages 46-57

   6. Reticuloendothelial Excretion Via the Bronchial Tree

      • T. Nicol, J. L. Cordingley

      Pages 58-62

   7. Kinetics of the Phagocytosis of Repeated Injections of Colloidal Carbon: Blockade, a Latent Period or Stimulation? A Question of Timing and Dose

      • Ernest L. Dobson, Lola S. Kelly, Caroline R. Finney

      Pages 63-73

3. Morphology

   1. Comparative Morphology of Macrophages in Tissue Culture

      • Boyce Bennett

      Pages 74-84

   2. Fine Structural Aspects of Reticuloendothelial Blockade

      • Joseph Wiener

      Pages 85-97

   3. The Cellular Basis of RE Stimulation: The Effects on Peritoneal Cells of Stimulation with Glyceryl Trioleate, Studied by EM and Autoradiography

      • I. Carr, M. A. Williams

      Pages 98-107

   4. Cytodynamics of Rat Lung in Response to Freund’s Adjuvant

      • Louis J. Casarett, George V. Metzger, Margaret G. Casarett

      Pages 108-120

   5. Esterase Histochemistry of Reticuloendothelial Cells

      • Bryan Ballantyne

      Pages 121-132

   6. Comparative Cytology of Alveolar and Peritoneal Macrophages from Germfree Rats

      • Eva S. Leake, Eugene R. Heise

      Pages 133-146

4. Factors Influencing and Regulating Activity

   1. The Role of the Environment in Determining the Discriminatory Activity of the Human Phagocytic Cell

      • A. E. Stuart

      Pages 147-162

   2. Some Effects of Divalent Cations on In Vitro Phagocytosis

      • G. V. Metzger, L. J. Casarett

      Pages 163-174

   3. The Engulfing Potential of Peritoneal Phagocytes of Conventional and Germfree Mice

      • E. H. Perkins, P. Nettesheim, T. Morita, H. E. Walburg Jr.

      Pages 175-187

   4. Pharmacological Stimulation and Depression of the Phagocytic Function of the RES

      • Kurt B. P. Flemming

      Pages 188-196

   5. The Action of Some Natural Substances on the RES

      • L. Bolis, R. W. I. Kessel, G. Petti

      Pages 197-202

   6. Effect of Bacillus Calmette Guerin on the Metabolism of Alveolar Macrophages

      • Quentin N. Myrvik, Dolores G. Evanst

      Pages 203-213

The circulatory system is usually considered to be composed of tubes of various diameters, characterized by collateral and terminal branches. There is also a tendency to treat blood vessels merely as conducting tubes in which the various structures of the wall act as mechanical pumps wlrich modify their diameter. This is, of course, not so. In fact, we know that blood vessels, and in particular arteries, are organs with personalities of their own and a particular susceptibility to several diseases. In addition, blood vessels differ in structure, according to their localization, and age at differing rates. The experimental work car­ ried out so far clearly confirms the data that have come from spontaneous human pathology; experimentally induced arterial lesions have a definite tendency to appear in certain arteries and not in others, depending on the experimental procedures used, and in each specific artery the lesions appear to have a specific location. We now know that the arterial wall is a metabo­ licallyactive structure, in which a number of enzyme activities have been clearly demonstrated. It possesses a sensitive vasa vasorum apparatus and a specific reactivity to various lesion-inducing stimuli. We must also remember that the arterial wall is in continuous contact with the blood circulating through the endothelial cells lining the vascular bed. It is obvious, therefore, that any variation in the circulating blood mass can modify the morphology as well as the function of the vessel wall.

• Lipoprotein
• age
• arteries
• artery
• atherosclerosis
• blood
• blood vessel
• cardiovascular
• cells
• diseases
• morphology
• pathology
• platelet

• Department of Physiology and Biophysics, University of Tennessee Medical Units, Memphis, USA

  Nicholas R. Di Luzio

• Institute of Pharmacology, University of Milan, Milan, Italy

  Rodolfo Paoletti

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