Advances in Experimental Medicine and Biology

Molecular Mechanisms of Neuronal Responsiveness

Authors: Ehrlich, Y.H., Lenox, R.H., Kornecki, E., Berry, W.O.

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About this book

The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep­ tor molecules have answered many quest ions regarding the nature of the ele­ ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus­ response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer­ ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis­ try, pharmacology, cell-biology, molecular genetics, neurology, and psy­ chiatry are required to achieve better understanding of the processes under­ lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu­ lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.

Table of contents (39 chapters)

Table of contents (39 chapters)
  • Further Studies on Depolarization Release Coupling in Squid Giant Synapse

    Pages 1-17

    Llinás, R. (et al.)

  • Temporal and Spatial Events in the Calcium Messenger System

    Pages 19-31

    Rasmussen, Howard (et al.)

  • Potassium Channels in Mouse Spinal Cord Cells

    Pages 33-43

    Kimura, J. E. (et al.)

  • Polyunsaturated Fatty Acids and Inositol Phospholipids at the Synapse in Neuronal Responsiveness

    Pages 45-68

    Bazan, Nicolas G. (et al.)

  • Receptor-Mediated Phosphoinositide Metabolism

    Pages 69-79

    Agranoff, Bernard W.

Buy this book

eBook $84.99
price for USA in USD
  • ISBN 978-1-4684-7618-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • Immediate eBook download after purchase and usable on all devices
  • Bulk discounts from 10 eBooks
Softcover $109.00
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Mechanisms of Neuronal Responsiveness
Authors
Series Title
Advances in Experimental Medicine and Biology
Series Volume
221
Copyright
1987
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-7618-7
DOI
10.1007/978-1-4684-7618-7
Softcover ISBN
978-1-4684-7620-0
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 563
Number of Illustrations
107 b/w illustrations
Topics