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Advances in Experimental Medicine and Biology

Gastrointestinal Hormones and Pathology of the Digestive System

Editors: Grossman, Morton (Ed.)

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About this book

The discovery that the same or similar peptides are present in endocrine cells and in neurons is one of the most exciting and provocative recent developments in biology. Suddenly neurophysiologists and endocrinologists have found that they have a great deal to discuss with each other. Substances originally isolated as hypothalamic hormones turn out to be abundantly present in neurons of other parts of the brain and in endocrine cells and neurons of the gut and pancreas. Similarly, substances originally isolated as gut hormones are found not only in gut endocrine cells but also in gut neurons and in brain neurons. It turns out that the group of peptides that we are accustomed to call gastrointestinal hormones are not all confined to the gastrointestinal tract and are not all solely hormones. We are learning that the chemical transmitters of the neurocrine, endocrine, and paracrine systems form a single group of related substances. This volume contains the latest installments in this fascinating story. It tells how these pep tides were isolated and their amino acid sequences determined, how the heterogeneity of most, perhaps all, of these peptides is being revealed as variant forms of them are discovered, how antibodies to these peptides are used as powerful tools to measure their concentrations in body fluids and to localize the cells in which they are synthesized and stored, and, finally, how the role of these substances in normal physiology and in pathological states is being unraveled.

Table of contents (40 chapters)

  • The Gastrointestinal Hormones: An Overview

    Gregory, R. A.

    Pages 1-4

  • A Short History of Digestive Endocrinology

    Grossman, M. I.

    Pages 5-10

  • Endocrine Cells of the Gastrointestinal Tract: General Aspects, Ultrastructure and Tumour Pathology

    Solcia, E. (et al.)

    Pages 11-22

  • How does a Candidate Peptide Become a Hormone?

    Grossman, M. I.

    Pages 23-25

  • Peptidergic Innervation of the Gastrointestinal Tract

    Polak, J. M. (et al.)

    Pages 27-49

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-7248-6
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-7250-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Gastrointestinal Hormones and Pathology of the Digestive System
Editors
  • Morton Grossman
Series Title
Advances in Experimental Medicine and Biology
Series Volume
106
Copyright
1978
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-7248-6
DOI
10.1007/978-1-4684-7248-6
Softcover ISBN
978-1-4684-7250-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 326
Number of Illustrations and Tables
32 b/w illustrations
Topics