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Applications of Molecular Genetics to Pharmacology

Molecular Biology of G-Protein-Coupled Receptors

Applications of Molecular Genetics to Pharmacology

Authors: Brann, M.

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About this book

LESLIE L. IVERSEN The present series of volumes is well timed, as the impact of molecular genetics on pharmacology has been profound, and a comprehensive review of the rapid advances of the past decade is much needed. Since the pioneering work of Dale, Ariens, and others in the early years of this century, much of pharmacology has been founded on the concept of receptors. To begin with, the receptor was conceived of as a "black box," which recognized and transduced the biological effects of neurotransmit­ ters, hormones, or other biological messengers-and which could also represent a target for man-made drugs. It is only in the last two decades that "molecular pharmacology" has blossomed, first with the advent of radioligand binding techniques and second messenger studies which greatly facilitated the biochemical study of drug-receptor interactions, and latterly with increasing knowledge of the molecular architecture of the receptor proteins themselves. This started with the traditional biochemical approach of isolating and purifying the receptor molecules. This proved to be a task of immense technical difficulty because of the low density of receptors in most biological source tissues, although there were some notable successes, e. g. , the purification of the nicotinic acetylcholine receptor from the electric organ of Torpedo. It was the ap­ plication of molecular genetics technology during the 1980s, however, which really accelerated progress in this field.

Table of contents (11 chapters)

Table of contents (11 chapters)
  • Rhodopsin

    Pages 1-30

    Ryba, Nicholas J. P. (et al.)

  • Structural, Functional, and Genetic Aspects of Receptors Coupled to G-Proteins

    Pages 31-61

    O’Dowd, Brian (et al.)

  • Genetic Analysis of the β-Adrenergic Receptor

    Pages 62-75

    Strader, Catherine D. (et al.)

  • The α-Adrenergic Receptors: New Subtypes, Pharmacology, and Coupling Mechanisms

    Pages 76-112

    Regan, John W. (et al.)

  • The 5-HT1A Receptor: From Molecular Characteristics to Clinical Correlates

    Pages 113-141

    Raymond, John R. (et al.)

Buy this book

eBook $74.99
price for USA in USD
  • ISBN 978-1-4684-6772-7
  • Digitally watermarked, DRM-free
  • Included format: PDF, EPUB
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $99.00
price for USA in USD
  • ISBN 978-1-4684-6774-1
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Biology of G-Protein-Coupled Receptors
Book Subtitle
Applications of Molecular Genetics to Pharmacology
Authors
Series Title
Applications of Molecular Genetics to Pharmacology
Copyright
1992
Publisher
Birkhäuser Basel
Copyright Holder
Birkhäuser Boston
eBook ISBN
978-1-4684-6772-7
DOI
10.1007/978-1-4684-6772-7
Softcover ISBN
978-1-4684-6774-1
Edition Number
1
Number of Pages
XVII, 326
Topics

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