Cell-Cell Interactions in the Release of Inflammatory Mediators

1. Front Matter

   Pages i-ix

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2. Leukocyte Adhesion: Molecular Basis and Relevance in Inflammation

   • Manuel Patarroyo, Lennart Lindbom, Claes Lundberg

   Pages 1-17

3. Products of Inflammatory Cells Synergistically Enhance Superoxide Production by Phagocytic Leukocytes

   • John A. Badwey, Jiabing Ding, Paul G. Heyworth, John M. Robinson

   Pages 19-33

4. Granulocyte-Macrophage Colony-Stimulating Factor and the Neutrophil: Mechanisms of Action

   • Julian Gomez-Cambronero, Ramadan I. Sha’afi

   Pages 35-71

5. Transcellular Metabolism of Arachidonic Acid in Platelets and Polymorphonuclear Leukocytes Activated by Physiological Agonists: Enhancement of Leukotriene B4Synthesis

   • Rémi Palmantier, Pierre Borgeat

   Pages 73-89

6. Interaction of Platelets and Neutrophils in the Generation of Sulfidopeptide Leukotrienes

   • Robert C. Murphy, Jacques Maclouf, Peter M. Henson

   Pages 91-101

7. Red Cell-Neutrophil Interactions in the Regulation of Active Oxygen Species and Lipoxygenase Products

   • Arnold Stern

   Pages 103-107

8. The Lipoxin Biosynthetic Circuit and their Actions with Human Neutrophils

   • Stefano Fiore, Mark E. Brezinski, Kelly-Ann Sheppard, Charles N. Serhan

   Pages 109-132

9. Hepoxilins Modulate Second Messenger Systems in the Human Neutrophil

   • Cecil R. Pace-Asciak, Santosh Nigam

   Pages 133-139

10. Regulated Secretion in Vascular Endothelium

    • Bruce M. Ewenstein, Brian C. Jacobson, Kimberly A. Birch

    Pages 141-157

11. Role of Eicosanoids and the Cytokine Network in Transmembrane Signaling in Vascular Cells

    • Kenneth B. Pomerantz, David P. Hajjar

    Pages 159-183

12. Lipoxins Inhibit Microvascular Inflammatory Actions of Leukotriene B4

    • Johan Raud, Ulla Palmertz, Sven-Erik Dahlén, Per Hedqvist

    Pages 185-192

13. PAF and TNFα Interactions in the Pathophysiology of Septic Shock

    • Reuven Rabinovici, Tian Li Yue, Jerome Vernick, Giora Feuerstein

    Pages 193-203

14. LTB4 and PAF in the Cytokine Network

    • Marek Rola-Pleszczynski

    Pages 205-221

15. Platelet-Activating Factor (PAF) - A Putative Mediator in Inflammatory Tissue Injury

    • Tian-Li Yue, Reuven Rabinovici, Giora Feuerstein

    Pages 223-233

16. Transcellular Metabolism of Leukotrienes in the Lung

    • Timothy D. Bigby

    Pages 235-250

17. The Role of Lipid Mediators in Oxygen-Induced Lung Injury

    • Ronald B. Holtzman, Joseph R. Hageman

    Pages 251-268

18. Interactions Between Macrophages and Granulocytes in Bronchial Asthma

    • James R. Wilkinson, Stephen J. Lane, Tak H. Lee

    Pages 269-279

19. Metabolism of Granulocyte-Derived Leukotriene A4 in Human Platelets and Respiratory Tissue: Transcellular Formation of Lipoxins and Leukotrienes

    • Charlotte Edenius, Leif Stenke, Susanne Tornhamre, Katarina Heidvall, Inger Forsberg, Barbro Näsman-Glaser et al.

    Pages 281-288

20. Metabolism of Arachidonic Acid by Isolated Lung Cells and Transcellular Biosynthesis of Thromboxanes

    • Karim Maghni, Chantal Robidoux, Johanne Laporte, Annie Hallée, Johanne Carrier, Pierre Borgeat et al.

    Pages 289-306

This volume constitutes. in part. the proceedings of the symposium on "Cell-Cell Interaction and Release of Inflammatory Mediators" organized by Drs. Patrick Y-K Wong and Charles N. Serhan and presented at the FASEB meeting in Washington. D.C. in April. 1990. It contains chapters by the symposium speakers as well as contributions from investigators in this field. Readers will find exciting advances in this volume. which contains chapters dedicated to state-of-the-art knowledge in the field of Cell-Cell Interaction and the functions of released mediators in inflammatory diseases. This book includes "cutting edge" investigations on transcellular eicosanoid biosynthesis. cytokines. PAF, and adhesion as well as interactions of inflammatory cells with endothe 1 i um. 1 ung • and kidney. A 1 so. the contro 1 and regu 1 at ion of renal function by lipid mediators generated during cell-cell i nteracti ons between rena 1 mesangi a 1 cells and 1 eukocytes has generated insight into the cell biology and regulatory role of these mediators in the kidney. Moreover. the relationship between these areas is discussed in sequelae of both asthmatic and renal diseases. We hope that some of the enthusiasm and excitement present in this research are also evident here and that this volume will serve as a reference for researchers. teachers. and students to survey thi s rapidly growing field.

• Colon
• Interleukin 1
• Lipid
• Macrophages
• Regulation
• leukocytes
• metabolism
• neutrophils
• physiology
• polymorphonuclear leukocytes

• New York Medical College, Valhalla, USA

  Patrick Y.-K. Wong

• Harvard Medical School, Boston, USA

  Charles N. Serhan

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