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Advances in Experimental Medicine and Biology

Cellular and Molecular Mechanisms in Hypertension

Editors: Cox, Robert H. (Ed.)

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  • ISBN 978-1-4684-6015-5
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About this book

Hypertension is recognized to be one of the major risk factors for the development of peripheral vascular disease. The last decade has witnessed several major advances in therapy for hypertension, including the development of angiotensin-converting enzyme inhibitors and calcium channel blockers. These compounds have greatly improved the ability to control blood pressure and to reduce the impact of this risk factor on morbidity and mortality. In spite of these advances, cardiovascular disease remains a major health problem in most modern industrialized countries with related deaths exceeding those from all other causes combined. In contrast to these advances in therapy, our understanding of the basic mechanisms responsible for the pathogenesis of hypertension remains incomplete. Recent studies have produced new insights into the nature of the regulation of muscle contraction in both heart and blood vessels as well as the changes in muscle function that occur in hypertension. However, the effects of antihypertensive therapy, both in terms of restoring normal function and in producing reversal of hypertension-associated changes, has not been as thoroughly studied, especially in the vasculature. Studies in the heart suggest that the efficacy of different therapeutic agents in restoring normal function and reversing hypertensive changes vary substantially with the mechanism of action of the therapeutic agent. It has also been recently determined that some therapeutic agents produce adverse effects on plasma lipid profiles, which could lead to the secondary acceleration of the atherosclerotic process, while at the same time normalizing blood pressure.

Table of contents (20 chapters)

  • Ionic Channels of Vascular Smooth Muscle in Hypertension

    Rusch, Nancy J. (et al.)

    Pages 1-7

  • Regulation of the Ca2+ Sensitivity of Vascular Smooth Muscle Contractile Elements

    Nishimura, Junji (et al.)

    Pages 9-25

  • Potassium Channel Activators in Vascular Smooth Muscle

    Cox, Robert H.

    Pages 27-43

  • Effects of Hypertension on Arterial Gene Expression and Atherosclerosis

    Chobanian, Aram V.

    Pages 45-53

  • Altered Phospholipase Activities Related to α1-Adrenergic Receptor Supersensitivity of Aortas from Aldosterone-Salt Hypertensive Rats

    Jones, Allan W. (et al.)

    Pages 55-69

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-6015-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-6017-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Cellular and Molecular Mechanisms in Hypertension
Editors
  • Robert H. Cox
Series Title
Advances in Experimental Medicine and Biology
Series Volume
308
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-6015-5
DOI
10.1007/978-1-4684-6015-5
Softcover ISBN
978-1-4684-6017-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
264
Topics