Advances in Experimental Medicine and Biology

Structure and Function of the Aspartic Proteinases

Genetics, Structures, and Mechanisms

Editors: Dunn, Ben M. (Ed.)

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About this book

In September, 1990, a group of 160 scientists from 19 countries and 21 of the United States met at the Red Lion Inn in Rohnert Park, Sonoma County, California. The purpose of this meeting was to share new information from recent research on the Aspartic Proteinases. This book is a compilation of the information transferred in that forum. The Aspartic Proteinases include all those enzymes from the "fourth" class of proteolytic enzymes, the first three being the Serine, Cysteine and Metalloproteinases. Of course, all the scientists in attendance at the Sonoma Aspartic Proteinase Conference would agree that our current level of understanding of the structure and function of the Aspartic Proteinase class of enzymes is clearly first class. The reasons for this require a bit of historical perspective. The group of scientists who are engaged in study of this family of enzymes first met as a separate entity in 1976, in Norman, Oklahoma, at a meeting organized by Jordan Tang of the Oklahoma Medical Research Foundation. This was an exciting time, as the first crystal structures of some of these enzymes were described by Blundell, James and Davies. During that conference, the relationship between the two halves of the mammalian and fungal enzymes was recognized and this has provided a structural foundation for analysis of the retroviral enzymes, which came later. A book was published by Plenum Press documenting l this conference, and the current book is an update to that important work.

Table of contents (49 chapters)

Table of contents (49 chapters)
  • Studies on Pepsin Mutagenesis and Recombinant Rhizopuspepsinogen

    Lin, X. L. (et al.)

    Pages 1-8

  • Inhibitor Binding Induces Structural Changes in Porcine Pepsin

    Abad-Zapatero, Cele (et al.)

    Pages 9-21

  • Functional Implications of the Three-Dimensional Structure of Bovine Chymosin

    Gilliland, Gary L. (et al.)

    Pages 23-37

  • Why Does Pepsin Have a Negative Charge at Very Low pH? An Analysis of Conserved Charged Residues in Aspartic Proteinases

    Andreeva, Natalia S. (et al.)

    Pages 39-45

  • X-Ray Structural Studies of Mammalian Aspartic Proteinases

    Cooper, J. B. (et al.)

    Pages 47-61

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-6012-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-6014-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Structure and Function of the Aspartic Proteinases
Book Subtitle
Genetics, Structures, and Mechanisms
Editors
  • Ben M. Dunn
Series Title
Advances in Experimental Medicine and Biology
Series Volume
306
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-6012-4
DOI
10.1007/978-1-4684-6012-4
Softcover ISBN
978-1-4684-6014-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
608
Topics