Regulation of Smooth Muscle Contraction

1. Front Matter

   Pages i-xii

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2. Tribute to Professor Edith Bülbring

   1. Tribute to Professor Edith Bülbring

      • Hirosi Kuriyama

      Pages 1-2

3. Contractile Protein Studies

   1. Structure-Function Relationships in Smooth Muscle Myosin Light Chain Kinase

      • Masaaki Ito, Vince Guerriero Jr., David J. Hartshorne

      Pages 3-10

   2. Regulation of Smooth Muscle Myosin Light Chain Kinase by Calmodulin

      • Anthony R. Means, Indrani C. Bagchi, Mark F. A. VanBerkum, Bruce E. Kemp

      Pages 11-24

   3. Regulation of Smooth Muscle Actomyosin Function

      • Mitsuo Ikebe, Toshiaki Mitsui, Shinsaku Maruta

      Pages 25-36

   4. Biochemical and Functional Characterization of Smooth Muscle Calponin

      • Steven J. Winder, Cindy Sutherland, Michael P. Walsh

      Pages 37-51

   5. In Vitro Evidence for Smooth Muscle Crossbridge Mechanical Interactions

      • David Warshaw, Kathleen Trybus

      Pages 53-59

4. Permeabilized Fiber Studies

   1. Regulation of a Smooth Muscle Contraction: A Hypothesis Based on Skinned Fiber Studies

      • Robert S. Moreland, Jan Willem R. Pott, Jacqueline Cilea, Suzanne Moreland

      Pages 61-75

   2. Cooperative Mechanisms in the Regulation of Smooth Muscle Contraction

      • Marion J. Siegman, Thomas M. Butler, Tapan Vyas, Susan U. Mooers, Srinivasa Narayan

      Pages 77-84

   3. Mechanics of the Crossbridge Interaction in Living and Chemically Skinned Smooth Muscle

      • Per Hellstrand

      Pages 85-96

   4. Modulation of Ca2+ Sensitivity by Agonists in Smooth Muscle

      • Toshio Kitazawa, Andrew P. Somlyo

      Pages 97-109

   5. Regulation of the Ca2+-Force Relationship in Permeabilized Arterial Smooth Muscle

      • Junji Nishimura, Suzanne Moreland, Robert S. Moreland, Cornelis van Breemen

      Pages 111-127

5. Intact Fiber Studies

   1. Myosin Light Chain Kinase Phosphorylation: Regulation of the Ca2+ Sensitivity of Contractile Elements

      • James T. Stull, Malú G. Tansey, R. Ann Word, Yasutaka Kubota, Kristine E. Kamm

      Pages 129-138

   2. Myosin Heavy Chain Isoforms and Smooth Muscle Function

      • Richard J. Paul, Timothy E. Hewett, Anne F. Martin

      Pages 139-145

   3. Mechanical and Biochemical Events During Hypoxia-Induced Relaxations of Rabbit Aorta

      • Suzanne Moreland, Ronald F. Coburn, Carl B. Baron, Robert S. Moreland

      Pages 147-157

   4. Can Different Four-State Crossbridge Models Explain Latch and the Energetics of Vascular Smooth Muscle?

      • Chi-Ming Hai, Christopher M. Rembold, Richard A. Murphy

      Pages 159-170

   5. Calcium Homeostasis in Single Intact Smooth Muscle Cells

      • Edwin D. W. Moore, Peter L. Becker, Takeo Itoh, Fredric S. Fay

      Pages 171-183

6. Excitation-Contraction Coupling

   1. Pharmacomechanical Coupling: The Membranes Talk to the Crossbridges

      • Andrew P. Somlyo, Toshio Kitazawa, Sei Kobayashi, Ming Cui Gong, Avril V. Somlyo

      Pages 185-208

   2. Characteristics of the Voltage-Dependent Calcium Channel in Smooth Muscle: Patch-Clamp Studies

      • Kenji Kitamura, Noriyoshi Teramoto, Masahiro Oike, Zhiling Xiong, Shunichi Kajioka, Yoshihito Inoue et al.

      Pages 209-227

   3. Changes in Cytoplasmic Calcium Induced by Purinergic P2x Receptor Activation in Vascular Smooth Muscle Cells and Sensory Neurons

      • Christopher D. Benham, Muriel M. Bouvier, Martyn L. Evans

      Pages 229-239

Sixth Annual Graduate Hospital Research Symposium REGULATION OF SMOOTH MUSCLE PROGRESS IN SOLVING THE PUZZLE Every so often a scientific conference comes at a time when everyone has new and exciting information, when old "dogmas" do not seem to be as well established, and when speakers and participants alike are ready to challenge interpretations of old and new experimental data. This was such a conference. What turns on a smooth muscle cell? The precise answer to this question has eluded scientists for much longer than I have been involved in the field. We know that an increase in cytosolic calcium is necessary and we know that phosphorylation of the 20 kDa myosin light chain is an important step in the process. We do not know if other processes are necessary for the initiation and lor maintenance of a smooth muscle contraction nor do we know if other processes modulate the regulation of contraction. The goal of the symposium on which this volume is based was to explore the most current hypotheses for the answers to these questions. I believe that after reading the chapters included in this volume, you will agree that this goal was achieved. The importance of calcium and calmodulin dependent myosin light chain phosphoryla­ tion in the regulation of smooth muscle contraction was reinforced by many presentations. However, the status of myosin light chain phosphorylation as a simple calcium dependent switch came under serious suspicion.

• ATP
• ATPase
• Asthma
• Calcium
• Nucleotide
• Purine
• endothelium
• mechanics
• smooth muscle

• Bockus Research Institute, The Graduate Hospital, USA

  Robert S. Moreland

• The University of Pennsylvania School of Medicine, Philadelphia, USA

  Robert S. Moreland

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