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Advances in Experimental Medicine and Biology

Red Blood Cell Aging

Editors: De Flora, Antonio, Magnani, Mauro (Eds.)

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  • ISBN 978-1-4684-5985-2
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About this book

The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.

Table of contents (33 chapters)

Table of contents (33 chapters)
  • Synthesis of the Transferrin Receptor in Peripheral Sheep Reticulocytes: Evidence for Incomplete Oligosaccharide Processing

    Pages 3-13

    Ahn, Jinhi (et al.)

  • The Loss of Enzyme Activity from Erythroid Cells During Maturation

    Pages 15-27

    Thorburn, David R. (et al.)

  • Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging

    Pages 29-35

    Magnani, Mauro (et al.)

  • Behaviour of Glucose-6-Phosphate Dehydrogenase during Erythroid Maturation

    Pages 37-43

    Cappellini, Maria D. (et al.)

  • KCl Cotransport in HbAA and HbSS Red Cells: Activation by Intracellular Acidity and Disappearance During Maturation

    Pages 47-57

    Ellory, J. Clive (et al.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5985-2
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-5987-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Red Blood Cell Aging
Editors
  • Antonio De Flora
  • Mauro Magnani
Series Title
Advances in Experimental Medicine and Biology
Series Volume
307
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5985-2
DOI
10.1007/978-1-4684-5985-2
Softcover ISBN
978-1-4684-5987-6
Series ISSN
0065-2598
Edition Number
1
Number of Pages
400
Topics