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  • Book
  • © 1991

Red Blood Cell Aging

Editors:

  1. Mauro Magnani

    1. University of Urbino, Urbino, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Antonio Flora

    1. University of Genoa, Genoa, Italy

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 307)

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Table of contents (33 chapters)

  1. Front Matter

    Pages i-x
    PDF

  2. Reticulocyte Maturation

    1. Front Matter

      Pages 1-1
      PDF

    3. The Loss of Enzyme Activity from Erythroid Cells During Maturation

      • David R. Thorburn, Ernest Beutler
      Pages 15-27

    4. Role and Mechanism of Hexokinase Decay During Reticulocyte Maturation and Cell Aging

      • Mauro Magnani, Luigia Rossi, Marzia Bianchi, Giordano Serafini, Vilberto Stocchi
      Pages 29-35

    5. Behaviour of Glucose-6-Phosphate Dehydrogenase during Erythroid Maturation

      • Maria D. Cappellini, Stefania Villa, Alessandro Gaviraghi, Franco Martinez di Montemuros, Dario Tavazzi, Daniela Panzeri et al.
      Pages 37-43

  3. Membranes

    1. Front Matter

      Pages 45-45
      PDF

    2. KCl Cotransport in HbAA and HbSS Red Cells: Activation by Intracellular Acidity and Disappearance During Maturation

      • J. Clive Ellory, Andrew C. Hall, Susan A. Ody, Carlos E. Poli de Figueiredos, Susan Chalder, John Stuart
      Pages 47-57

    3. Conformational Changes and Oxidation of Membrane Proteins in Senescent Human Erythrocytes

      • Augusta Brovelli, Maria A. Castellana, Giampaolo Minetti, Giampiero Piccinini, Claudio Seppi, Maria R. De Renzis et al.
      Pages 59-73

    4. Selective Binding of Met-Hemoglobin to Erythrocytic Membrane: A Possible Involvement in Red Blood Cell Aging

      • Bruno Giardina, Roberto Scatena, Maria E. Clementi, Maria T. Ramacci, Franco Maccari, Loredana Cerroni et al.
      Pages 75-84

    5. Diabetes Mellitus and Red Blood Cell Aging: A Structural and Functional Study

      • Laura Mazzanti, Rosa A. Rabini, Roberto Staffolani, Emanuela Faloia, Roberto De Pirro, Armanda Pugnaloni et al.
      Pages 85-89

  4. Metabolism

    1. Front Matter

      Pages 91-91
      PDF

    2. Characterization of Senescent Red Cells from the Rabbit

      • George L. Dale, Robert B. Daniels, Joshua Beckman, Shannon L. Norenberg
      Pages 93-103

    4. The Relationship Between the Blood Oxygen Transport and the Human Red Cell Aging Process

      • Michele Samaja, Ermanna Rovida, Roberto Motterlini, Massimo Tarantola
      Pages 115-123

    5. Red Cell Metabolism, Normal and Abnormal Implications for Red Cell Aging

      • William N. Valentine, Donald E. Paglia
      Pages 125-137

    6. Significance and Relevance of NAD Synthesis in Human Erythrocyte Life Span

      • Vanna Micheli, Silvia Sestini, Marina Rocchigiani, Monica Pescaglini, Carlo Ricci
      Pages 139-146

  5. Protein Modifications

    1. Front Matter

      Pages 147-147
      PDF

    2. Hypotheses on the Physiological Role of Enzymatic Protein Methyl Esterification Using Human Erythrocytes as a Model System

      • Patrizia Galletti, Caterina Manna, Diego Ingrosso, Patrizia Iardino, Vincenzo Zappia
      Pages 149-160

    3. Heterogeneity of Guanine Nucleotide Binding Proteins in Human Red Blood Cell Membranes

      • Antonio De Flora, Gianluca Damonte, Adina Sdraffa, Luisa Franco, Umberto Benatti
      Pages 161-171
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About this book

The mammalian erythrocyte is a very suitable model for the study of aging at the cellular and molecular level. It is not only a matter of apparent simplicity in terms of biochemistry, biophysics and physiology but more likely this cell offers a great possibility for elucidating some basic problems in the process of aging. In fact, nowadays, it is possible to follow individual cells all along their life span in circulation, it is possible to obtain these cells when young, middle aged or old and it is possible to obtain cells from individuals of defined ages and transfuse them into compatible recipients to investigate the role of the environment where the cell lives, and finally it is possible to easily manipulate the red cell content in terms of enzymatic activities and/or metabolic properties to investigate the possible effect of these manipulations on cell survival. This book, Red Blood Cell Aging, is based on a symposium held in Urbino, Italy, at the end of 1990 and examines the impact of age on the membrane, metabolism, structural and enzymatic proteins of mammalian erythrocytes. The various contributions to this symposium not only described those processes of aging which affect the cell but also provided a nearly complete picture of the event{s} and mechanism{s} that every day permits to recognize among 25 trillion circulating red cells {in an average adult} that 1 percent that have reached the end of their 120 day life span in circulation.
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Keywords

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Editors and Affiliations

  • University of Urbino, Urbino, Italy

    Mauro Magnani

  • University of Genoa, Genoa, Italy

    Antonio Flora

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Bibliographic Information

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Buy it now

eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

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