Mechanisms of Anesthetic Action in Skeletal, Cardiac, and Smooth Muscle

1. Front Matter

   Pages i-ix

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2. Skeletal Muscle

   1. Front Matter

      Pages 1-1

      PDF

   2. Skeletal Muscle Targets for the Action of Anesthetic Agents

      • Thomas E. Nelson

      Pages 3-8

   3. Effects of Lipid-Soluble Agents on Sodium Channel Function in Normal and MH-Susceptible Skeletal Muscle Cultures

      • Steven J. Wieland, Jeffrey E. Fletcher, Qi-hua Gong, Henry Rosenberg

      Pages 9-19

   4. Effect of Halothane on Human Skeletal Muscle Sarcoplasmic Reticulum Calcium-Release Channel

      • Thomas E. Nelson

      Pages 21-30

   5. Ca Release from Skeletal Muscle SR

      • G. Salviati, S. Ceoldo, G. Fachechi-Cassano, R. Betto

      Pages 31-41

   6. Halothane-Cooling Contractures and Regulation of the Myoplasmic Ca2+ Concentration in Skeletal Muscle

      • Roberto Takashi Sudo, Guilherme Suarez-Kurtz

      Pages 43-55

   7. Interactions of Fatty Acids with the Calcium Release Channel in Malignant Hyperthermia

      • Jeffrey E. Fletcher, Henry Rosenberg, Jill Beech

      Pages 57-69

   8. Transitional Concepts: Skeletal — Cardiac Muscle

      1. Why Does Halothane Relax Cardiac Muscle but Contract Malignant Hyperthermic Skeletal Muscle?

         • S. Tsuyoshi Ohnishi, Masayuki Katsuoka

         Pages 73-87

3. Cardiac Muscle

   1. Front Matter

      Pages 89-89

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   2. Cardiac Effects of Anesthetics

      • Zeljko J. Bosnjak

      Pages 91-96

   3. Effects of Volatile Anesthetics on the Intracellular Calcium Transient and Calcium Current in Cardiac Muscle Cells

      • Zeljko J. Bosnjak

      Pages 97-107

   4. Halothane Inhibits Binding of Calcium Channel Blockers to Cardiac Sarcolemma

      • Benjamin Drenger, Susan Riggs Runge, Paul Hoehner, Mary Quigg, Thomas J. J. Blanck

      Pages 109-114

   5. Contribution of the Known Subcellular Effects of Anesthetics to Their Negative Inotropic Effect in Intact Myocardium

      • Hirochika Komai, Ben F. Rusy

      Pages 115-123

   6. Effects of Volatile Anesthetics on the Intracellular Ca2+ Concentration in Cardiac Muscle Cells

      • Dixon W. Wilde, Ravi Gutta, Michael F. Haney, Paul R. Knight

      Pages 125-141

   7. Effects of Volatile Anesthetics on Cardiac Sarcoplasmic Reticulum as Determined in Intact Cells

      • David M. Wheeler, Ana Katz, R. Todd Rice

      Pages 143-154

   8. Alcohol and Anesthetic Actions on Myocardial Contractility

      • Carl Lynch III

      Pages 155-167

   9. Volatile Anesthetics and Second Messengers in Cardiac Tissue

      • Yvonne Vulliemoz

      Pages 169-180

   10. The Effects of Volatile Anesthetics on the Calcium Sensitivity of Cardiac Myofilaments

       • Isabelle Murat, Renée Ventura-Clapier

       Pages 181-190

   11. Evidence for a Halothane-Induced Reduction in Maximal Calcium-Activated Force in Mammalian Myocardium

       • Michael R. Berman, Eugenie S. Casella, Thomas J. J. Blanck

       Pages 191-197

The volatile anesthetics continue to be one of the most mysterious yet commonly used class of drugs in medical practice today. A prominent and troublesome side effect of volatile anesthetics is their ability to alter hemodynamics. This arises from two diverse but interrelated phenomena, depression of cardiac contractility and dilation of the vasculature. These effects of volatile anesthetics on cardiac and smooth muscle plus the action of volatile anesthetics on skeletal muscle in the malignant hyperthermic syndrome have led to concern about the interaction of volatile anesthetics (and other anesthetic agents) with calcium metabolism in the muscle cell. Many of the phenomena caused by anesthetics appear to have common mechanisms in all of the muscle types; however, the differences among skeletal, cardiac and smooth muscle also lead to distinct effects of the anesthetics in each. Given the diverse research disciplines which have been brought to hear on the mechanism of anesthetic alteration of contractility, the symposium from which this book originates was convened for the purpose of gathering those with common interests in anesthetic agents and their cellular and subcellular actions in muscle. The recent symposium had its origins in a small but exciting meeting that took place at the University of Texas at Houston in 1984. At that time, Robert Merin and Jacques Chelly convened a group of people who had interest in cardiac muscle and calcium antagonists.

• Calcium
• depression
• hemodynamics
• lead
• metabolism
• research

• Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, USA

  Thomas J. J. Blanck, David M. Wheeler

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