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Advances in Experimental Medicine and Biology

Mechanisms of Anesthetic Action in Skeletal, Cardiac, and Smooth Muscle

Editors: Blanck, Thomas J.J., Wheeler, David M. (Eds.)

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About this book

The volatile anesthetics continue to be one of the most mysterious yet commonly used class of drugs in medical practice today. A prominent and troublesome side effect of volatile anesthetics is their ability to alter hemodynamics. This arises from two diverse but interrelated phenomena, depression of cardiac contractility and dilation of the vasculature. These effects of volatile anesthetics on cardiac and smooth muscle plus the action of volatile anesthetics on skeletal muscle in the malignant hyperthermic syndrome have led to concern about the interaction of volatile anesthetics (and other anesthetic agents) with calcium metabolism in the muscle cell. Many of the phenomena caused by anesthetics appear to have common mechanisms in all of the muscle types; however, the differences among skeletal, cardiac and smooth muscle also lead to distinct effects of the anesthetics in each. Given the diverse research disciplines which have been brought to hear on the mechanism of anesthetic alteration of contractility, the symposium from which this book originates was convened for the purpose of gathering those with common interests in anesthetic agents and their cellular and subcellular actions in muscle. The recent symposium had its origins in a small but exciting meeting that took place at the University of Texas at Houston in 1984. At that time, Robert Merin and Jacques Chelly convened a group of people who had interest in cardiac muscle and calcium antagonists.

Table of contents (27 chapters)

Table of contents (27 chapters)
  • Skeletal Muscle Targets for the Action of Anesthetic Agents

    Pages 3-8

    Nelson, Thomas E.

  • Effects of Lipid-Soluble Agents on Sodium Channel Function in Normal and MH-Susceptible Skeletal Muscle Cultures

    Pages 9-19

    Wieland, Steven J. (et al.)

  • Effect of Halothane on Human Skeletal Muscle Sarcoplasmic Reticulum Calcium-Release Channel

    Pages 21-30

    Nelson, Thomas E.

  • Ca Release from Skeletal Muscle SR

    Pages 31-41

    Salviati, G. (et al.)

  • Halothane-Cooling Contractures and Regulation of the Myoplasmic Ca2+ Concentration in Skeletal Muscle

    Pages 43-55

    Sudo, Roberto Takashi (et al.)

Buy this book

eBook  
  • ISBN 978-1-4684-5979-1
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
Softcover  
  • ISBN 978-1-4684-5981-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
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Bibliographic Information

Bibliographic Information
Book Title
Mechanisms of Anesthetic Action in Skeletal, Cardiac, and Smooth Muscle
Editors
  • Thomas J.J. Blanck
  • David M. Wheeler
Series Title
Advances in Experimental Medicine and Biology
Series Volume
301
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5979-1
DOI
10.1007/978-1-4684-5979-1
Softcover ISBN
978-1-4684-5981-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
320
Topics

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