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Advances in Experimental Medicine and Biology

Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Editors: LeRoith, Derek, Raizada, Mohan K. (Eds.)

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  • ISBN 978-1-4684-5949-4
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About this book

This volume addresses a fundamental puzzle in biology and medicine, namely, how does tissue develop, repair and replace itself. The answer appears to lie in growth factors and their regulation. To thrive and survive we need growth factors and this book concentrates on two factors that are related to growth hormone. Growth hormone does not act directly on all tissues, but mediates many of its actions through the release of insulin-like growth factors from the liver. The growth factors were originally called somatomedins by McConaghey and Sledge (1), who discovered that they mediated growth-like effects of growth hormone. However, the factors were purified on the basis of their insulinomimetic actions on fat and muscle and it is their relationship to the insulin family of pep tides that now gives them their name (2,3) of insulin-like growth factors (IGFs). They mediate the actions of. growth hormone on the proteoglycan synthesis of cartilage and produce mitogenic effects in fibroblast cultures.

Table of contents (44 chapters)

Table of contents (44 chapters)
  • Structural and Regulatory Aspects of the Human Genes Encoding IGF-I and -II

    Pages 1-14

    Sussenbach, J. S. (et al.)

  • Structural and Functional Characterization of IGF-I RNA 3’ Variants

    Pages 15-21

    Lund, P. Kay (et al.)

  • Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins

    Pages 23-30

    Cascieri, Margaret A. (et al.)

  • Insulin-Like Growth Factor II: Complexity of Biosynthesis and Receptor Binding

    Pages 31-44

    Gammeltoft, Steen (et al.)

  • Development of a Specific Radioimmuno Assay for E Domain Containing Forms of Insulin-Like Growth Factor II

    Pages 45-56

    Perdue, James F. (et al.)

Buy this book

eBook $139.00
price for USA in USD
  • ISBN 978-1-4684-5949-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $179.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors
Editors
  • Derek LeRoith
  • Mohan K. Raizada
Series Title
Advances in Experimental Medicine and Biology
Series Volume
293
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5949-4
DOI
10.1007/978-1-4684-5949-4
Softcover ISBN
978-1-4684-5951-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
498
Topics