Drugs of Abuse, Immunity, and Immunodeficiency

1. Front Matter

   Pages i-xii

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2. Immunopharmacology and Immunotoxicology

   • John W. Hadden

   Pages 1-11

3. Neuroimmunopharmacologic Effects of Drugs of Abuse

   • Nicholas R. S. Hall, Maureen P. O’Grady, Robert A. Menzies

   Pages 13-23

4. Altered Serum Immunoglobulin Concentration in Chronic Marijuana Smokers

   • Gabriel G. Nahas, Eliott F. Osserman

   Pages 25-32

5. Advanced Malignancy in the Young Marijuana Smoker

   • Paul J. Donald

   Pages 33-46

6. Effects of Marijuana on Human Natural Killer Cell Activity

   • Steven Specter, Gerald Lancz

   Pages 47-56

7. Adverse Effect of Δ9-Tetrahydrocannabinol on Human Neutrophil Function

   • Julie Y. Djeu, Min Wang, Herman Friedman

   Pages 57-62

8. Influence of Marijuana Components (THC and CBD) on Human Mononuclear Cell Cytokine Secretion In vitro

   • Bernhard Watzl, Philip Scuderi, Ronald R. Watson

   Pages 63-70

9. Effect of Stereospecific Cannabinoids on the Immune System

   • A. M. Zimmerman, N. Titishov, R. Mechoulam, S. Zimmerman

   Pages 71-80

10. Drugs of Abuse and Experimental Autoimmune Diseases

    • William D. Lyman

    Pages 81-92

11. Effects of Marijuana on Macrophage Function

    • G. A. Cabral, R. Vásquez

    Pages 93-105

12. Cannabinoid Induced Changes in Eicosanoid Synthesis by Mouse Peritoneal Cells

    • Sumner Burstein

    Pages 107-112

13. Suppression of T Lymphocyte Subpopulations by THC

    • Susan Pross, Catherine Newton, Thomas Klein, Ray Widen, Judy Smith, Herman Friedman

    Pages 113-117

14. Drugs of Abuse and Infections

    • S. G. Bradley

    Pages 119-125

15. Effect of Delta-9-Tetrahydrocannabinol on Mitogenic and Antigenic Stimulation of Lymphoid Cells from Inbred Hamsters Infected with Treponema Pallidum Subsp. Pallidum

    • Lois J. Paradise, Angela Pruitt, Andrew W. O’B. Burgess

    Pages 127-133

16. Combined Immunosuppressive Activities of Delta-9-Tetrahydrocannabinol and Murine Retrovirus

    • Steven Specter, Gerald Lancz, Gina Westrich, Herman Friedman

    Pages 135-141

17. Effects of Cocaine and Other Drugs of Abuse on Immune Function

    • Robert M. Donahoe, Arthur Falek, John J. Madden, Janet K. A. Nicholson, Peter Bokos, Karl Gallegos et al.

    Pages 143-150

18. Cocaine Effects on Cultured Lymphocytes

    • Thomas W. Klein, Catherine Newton, Herman Friedman

    Pages 151-158

19. In vivo and In vitro Studies of Opiates and Cellular Immunity in Narcotic Addicts

    • David M. Novick, Miriam Ochshorn, Mary Jeanne Kreek

    Pages 159-170

20. Opiates, Human Peripheral Blood Mononuclear Cells, and HIV

    • Phillip K. Peterson, Burt M. Sharp, Genya Gekker, Brooks Jackson, Henry H. Balfour Jr.

    Pages 171-178

This volume is based on the program of the International Conference on Drugs of Abuse, Immunity and Immunodeficiency held in Clearwater Beach, Florida. It was sponsored by the University of South Florida College of Medicine with the support of the National Institute on Drug Abuse. During the past few decades, drugs of abuse, including marijuana, cocaine, opiates and alcohol, have been studied by biomedical scientists in terms of the systemic effects of the drugs as well as alterations in neurophysiology and the psychology. More recently, the scope of such investigations has been broadened to include alterations within the immune system, and the influence of altered immunity on physiological and psychological consequences of drug abuse. In this regard, participants in the Clearwater Beach conference provided new information concern­ ing both basic and clinical aspects of drugs of abuse and immunity, especially immunodeficiency. Advances have been made in recent years in understanding the nature and mechanisms regulating the immune response and the mechanisms by which drugs may influence immune responses. In particular, the emergence of psychoneuroimmunology as a new discipline has heightened interest in immune responses influenced by psychoactive drugs. This has resulted in interdisciplinary investigations involving clinical and basic scientists including microbiologists, immu­ nologists, physiologists, psychiatrists, oncologists and others. The recreational use of the above mentioned drugs by large numbers of individuals has aroused serious concern about the consequences of this activity.

• cocaine
• drug
• drug abuse
• drugs of abuse
• immune system
• immunodeficiency
• immunology
• marijuana
• physiology
• psychology
• system

• The University of South Florida, Tampa, USA

  Herman Friedman, Steven Specter, Thomas W. Klein

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