Advances in Experimental Medicine and Biology

Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

Editors: Malmendier, Claude L., Alaupovic, P., Brewer, H. Bryan (Eds.)

Free Preview

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5904-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-5906-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the genetics of apo 1 ipoprote ins , their transcriptional regulation, the amino acid mutations of the apo B gene and of the LOL receptor gene, the structural domains and the acylation sites of apoprotein B.

Table of contents (45 chapters)

Table of contents (45 chapters)
  • Transcriptional Regulation of the Human Apolipoprotein Genes

    Zannis, Vassilis I. (et al.)

    Pages 1-23

  • Mutations and Variants of Apolipoprotein B that Affect Plasma Cholesterol Levels

    Innerarity, Thomas L. (et al.)

    Pages 25-31

  • Molecular Genetics of Familial Hypercholesterolemia

    Aalto-Setälä, Katriina (et al.)

    Pages 33-37

  • Investigation of Structural Domains in Human Serum Low Density Lipoprotein Apolipoprotein B100

    Djavaheri, Mojgan (et al.)

    Pages 39-48

  • Implications of Thiolester Linked Fatty Acids in Apolipoprotein B

    Lee, Diana M.

    Pages 49-58

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5904-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-5906-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics
Editors
  • Claude L. Malmendier
  • P. Alaupovic
  • H. Bryan Brewer
Series Title
Advances in Experimental Medicine and Biology
Series Volume
285
Copyright
1991
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5904-3
DOI
10.1007/978-1-4684-5904-3
Softcover ISBN
978-1-4684-5906-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
454
Topics