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Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

  • Book
  • © 1991

Overview

Editors:
  1. Claude L. Malmendier

    1. Research Foundation on Atherosclerosis, Brussels, Belgium

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  2. P. Alaupovic

    1. Lipoprotein and Atherosclerosis Resaerch Program, Oklahoma Medical Research Foundation, Oklahoma City, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. H. Bryan Brewer

    1. Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 285)

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Table of contents (50 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Cholesterol Metabolism

    1. Front Matter

      Pages xi-xi
      Download chapter PDF

    2. Transcriptional Regulation of the Human Apolipoprotein Genes

      • Vassilis I. Zannis, Dimitris Kardassis, Kinya Ogami, Margarita Hadzopoulou-Cladaras, Christos Cladaras
      Pages 1-23

    3. Mutations and Variants of Apolipoprotein B that Affect Plasma Cholesterol Levels

      • Thomas L. Innerarity, Kristina Boström
      Pages 25-31

    4. Molecular Genetics of Familial Hypercholesterolemia

      • Katriina Aalto-Setälä, Kimmo Kontula
      Pages 33-37

    5. Investigation of Structural Domains in Human Serum Low Density Lipoprotein Apolipoprotein B100

      • Mojgan Djavaheri, Lawrence P. Aggerbeck
      Pages 39-48

    6. Implications of Thiolester Linked Fatty Acids in Apolipoprotein B

      • Diana M. Lee
      Pages 49-58

    7. Factors Regulating the Distribution of Cholesterol Between LDL and HDL

      • P. J. Barter, L. B. F. Chang, O. V. Rajaram
      Pages 59-64

    8. Regulation of Hepatic Lipase Expression by an Intermediate of the Cellular Cholesterol Biosynthetic Pathway

      • Steven J. Busch, Gary A. Martin, Roger L. Barnhart, Margaret A. Flanagan, Richard L. Jackson
      Pages 65-69

    9. Human Plasma Lecithin:Cholesterol Acyltransferase (LCAT) On the role of essential carboxyl groups in catalysis

      • Matti Jauhiainen, Peter J. Dolphin
      Pages 71-75

    10. Plasma Lipoprotein Phenotype in Response to Cholesteryl Ester Transfer Protein Levels in Dyslipoproteinemia

      • Yves L. Marcel, Alan R. Tall, Mireille Hogue, Ross W. Milne, Ruth McPherson
      Pages 77-80

    11. HDL Receptor-Mediated Cholesterol Efflux from Cells and its Regulattion

      • E. L. Bierman, J. Oram, A. Mendez
      Pages 81-83

    12. Binding of Apolipoproteins A to Adipose Cells : Role of Receptor Sites in Cholesterol Efflux and Purification of Binding Protein(S)

      • Ronald Barbaras, Pascal Puchois, Anne Pradines Figuères, Armin Steinmetz, Véronique Clavey, Nordine Ghalim et al.
      Pages 85-92

    13. Lipoprotein A-I Containing Particles

      • Nicolas Duverger, Nordine Ghalim, Nathalie Theret, Philippe Duchateau, Gustave Aguie, Gérard Ailhaud et al.
      Pages 93-99

    14. Distribution of Cholesterol within High Density Lipoproteins Fractionated by Immunoaffinity Chromatography

      • Daniel Pometta, Richard W. James
      Pages 101-107

    15. Metabolic Role of Human Apoprotein A-IV

      • L. Lagrost, P. Gambert, A. Athias, C. Lallemant
      Pages 109-115

    16. Regression of Atheroma and Putative Role of CETP in Cholesteryl Ester Removal

      • Yechezkiel Stein, Olga Stein
      Pages 117-122

    17. Symmetry of the Surface, and Structure of the Central Core of Human LDL Particles, Analyzed by X-Ray Small Angle Scattering

      • M. W. Baumstark, W. Kreutz, A. Berg, J. Keul
      Pages 123-130

    18. Role of Amphipathic Helixes in HDL Structure/Function

      • G. M. Anantharamaiah, C. G. Brouillette, J. A. Engler, H. De Loof, Y. V. Venkatachalapathi, J. Boogaerts et al.
      Pages 131-140

    19. Conformational Properties of Apolipoproteins Studied by Computer Graphics

      • J-L. De Coen, J-P. Kocher, C. Delcroix, J-F. Lontie, C. L. Malmendier
      Pages 141-145
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Keywords

About this book

The past two decades have seen steady progress in our understanding of the pathogenesis of atherosclerosis. The role of low density lipoprotein (LOL) increase and of LOL receptor deficiency or malfunctions in familial hypercholesterolemia has been largely enlightened by the works of Brown and Goldstein. These authors postulated also that modification of LOL to a form recognized by the scavenger or acetyl-LOL receptor may be required for lipid loading of macrophage-derived foam cells in the lesions. A growing body of evidence suggests that oxidative modification of LOL could enhance its atherogenicity by its implication as a factor in the generation of foam cells. Thus, if the role of LOL in the pathogenesis of hypercholesterolemia was well established a great deal of information appears currently on new approaches such as the mechanisms leading to the accumulation of foam cells, the impact of LOL structural alterations, notably oxidation and the role of gene mutations of apolipoprotein Band/or LOL receptor The opening topic is devoted to these new avenues outlined in the field of hypercholesterolemia. The first part concerns the genetic aspects of atherosclerosis: mainly the genetics of apo 1 ipoprote ins , their transcriptional regulation, the amino acid mutations of the apo B gene and of the LOL receptor gene, the structural domains and the acylation sites of apoprotein B.

Editors and Affiliations

  • Research Foundation on Atherosclerosis, Brussels, Belgium

    Claude L. Malmendier

  • Lipoprotein and Atherosclerosis Resaerch Program, Oklahoma Medical Research Foundation, Oklahoma City, USA

    P. Alaupovic

  • Molecular Disease Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, USA

    H. Bryan Brewer

Bibliographic Information

  • Book Title: Hypercholesterolemia, Hypocholesterolemia, Hypertriglyceridemia, in Vivo Kinetics

  • Editors: Claude L. Malmendier, P. Alaupovic, H. Bryan Brewer

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5904-3

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1991

  • Softcover ISBN: 978-1-4684-5906-7Published: 14 June 2012

  • eBook ISBN: 978-1-4684-5904-3Published: 13 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 454

  • Topics: Diabetes, Internal Medicine, Biochemistry, general, Human Genetics

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