Advances in Experimental Medicine and Biology

Biological Reactive Intermediates IV

Molecular and Cellular Effects and Their Impact on Human Health

Editors: Witmer, C.M., Snyder, R.R., Jollow, D.J., Kalf, G.F., Kocsis, J.J. (Eds.)

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  • ISBN 978-1-4684-5877-0
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Softcover 155,99 €
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About this book

The finding that chemicals can be metabolically activated to yield reactive chemical species capable of covalently binding to cellular macromolecules and the concept that these reactions could initiate toxicological and carcinogenic events stimulated a meeting by a small group of toxicologists at the University of Turku, in Finland, in 1975 (Jollow et al. , 1977). The growing interest in this field of research led to subsequent symposia at the University of Surrey, in England in 1980 (Snyder et al. , 1982), and the University of Maryland in the U. S. A. in 1985 (Kocsis et al. , 1986). The Fourth International Symposium on Biological Reactive Intermediates was hosted by the Center for Toxicology at the University of Arizona and convened in Tucson, Arizona, January 14-17, 1990. Over 300 people attended. There were 60 platform presentations by invited speakers, and 96 volunteer communications in the form of posters were offered. These meetings have grown from a small group of scientists working in closely related areas to a major international series of symposia which convene every five years to review, and place in context, the latest advances in our understanding of the formation, fate and consequences of biological reactive intermediates. The Organizing Committee: Allan H. Conney, Robert Snyder (Co-chairman), and Charlotte M. Witmer (Rutgers University, Piscataway, NJ), David J. Jollow Co­ chairman) (Medical University, South Carolina, Charleston, SC), 1. Glenn Sipes (Co­ chairman) (University of Arizona, Tucson, AZ), James J. Kocsis and George F.

Table of contents (49 chapters)

  • Cytochrome P-450 Oxidations and the Generation of Biologically Reactive Intermediates

    Guengerich, F. Peter (et al.)

    Pages 1-11

    Preview Buy Chapter 30,19 €
  • Formation of Reactive Intermediates by Phase II Enzymes: Glutathione-Dependent Bioactivation Reactions

    Vamvakas, Spyridon (et al.)

    Pages 13-24

    Preview Buy Chapter 30,19 €
  • Role of the Well-Known Basic and Recently Discovered Acidic Glutathione S-Transferases in the Control of Genotoxic Metabolites

    Oesch, Franz (et al.)

    Pages 25-39

    Preview Buy Chapter 30,19 €
  • Bioactivation of Xenobiotics by Flavin-Containing Monooxygenases

    Ziegler, Daniel M.

    Pages 41-50

    Preview Buy Chapter 30,19 €
  • Formation of Biological Reactive Intermediates by Peroxidases: Halide Mediated Acetaminophen Oxidation and Cytotoxicity

    O’Brien, Peter J. (et al.)

    Pages 51-64

    Preview Buy Chapter 30,19 €

Buy this book

eBook 118,99 €
price for Spain (gross)
  • ISBN 978-1-4684-5877-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover 155,99 €
price for Spain (gross)
  • ISBN 978-1-4684-5879-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
  • The final prices may differ from the prices shown due to specifics of VAT rules
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Bibliographic Information

Bibliographic Information
Book Title
Biological Reactive Intermediates IV
Book Subtitle
Molecular and Cellular Effects and Their Impact on Human Health
Editors
  • Charlotte M. Witmer
  • Robert R. Snyder
  • David J. Jollow
  • George F. Kalf
  • James J. Kocsis
Series Title
Advances in Experimental Medicine and Biology
Series Volume
283
Copyright
1991
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5877-0
DOI
10.1007/978-1-4684-5877-0
Softcover ISBN
978-1-4684-5879-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
912
Number of Illustrations and Tables
87 b/w illustrations
Topics