Genetic Toxicology of Complex Mixtures

1. Front Matter

   Pages i-ix

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2. Development and Application of New Methodologies Applicable to Research on Complex Environmental Mixtures

   1. Development and Application of New Methodologies Applicable to Research on Complex Environmental Mixtures

      • P. H. M. Lohman, E. W. Vogel, B. Morolli, A. A. v. Zeeland, H. Vrieling

      Pages 1-9

3. Complex Mixtures of Genotoxicants in Air

   1. Identification of Genotoxic Agents in Complex Mixtures of Air Pollutants

      • Dennis Schuetzle, Joan M. Daisey

      Pages 11-32

   2. Human Exposure to Airborne Mutagens Indoors and Outdoors Using Mutagenesis and Chemical Analysis Methods

      • Hidetsuru Matsushita, Sumio Goto, Yukihiko Takagi, Osamu Endo, Kiyoshi Tanabe

      Pages 33-56

   3. Genetic Toxicology of Airborne Particulate Matter Using Cytogenetic Assays and Microbial Mutagenicity Assays

      • Roberto Barale, Lucia Migliore, Bettina Cellini, Lucia Francioni, Francesco Giorgelli, Italo Barrai et al.

      Pages 57-71

   4. Indoor and Outdoor Sources of Airborne Mutagens in Nonurban Areas

      • J. J. van Houdt, G. M. Alink

      Pages 73-87

   5. Characterization of Mutagen Sources in Urban Particulate Matter in Gothenburg, Sweden

      • Göran Löfroth

      Pages 89-101

   6. Assessment of the Mutagenicity of Volatile Organic Air Pollutants Before and After Atmospheric Transformation

      • Larry D. Claxton, T. E. Kleindienst, Erica Perry, Larry T. Cupitt

      Pages 103-111

   7. Carcinogenicity of Complex Mixtures in Air Using In Vitro and In Vivo Assays

      • I. Chouroulinkov

      Pages 113-125

   8. Contribution of Polycyclic Aromatic Hydrocarbons and Other Polycyclic Aromatic Compounds to the Carcinogenicity of Combustion Source and Air Pollution

      • G. Grimmer, H. Brune, G. Dettbarn, J. Jacob, J. Misfeld, U. Mohr et al.

      Pages 127-140

   9. Old and New Carcinogens

      • Lorenzo Tomatis

      Pages 141-147

   10. Experimental and Epidemiologic Applications to Cancer Risk Assessment of Complex Mixtures

       • Marja Sorsa, Harri Vainio, Anthony J. McMichael

       Pages 149-155

   11. Mutagenicity, Carcinogenicity, and Human Cancer Risk from Indoor Exposure to Coal and Wood Combustion in Xuan Wei, China

       • Judy L. Mumford, Robert S. Chapman, Stephen Nesnow, C. Tuker Helmes, Xueming Li

       Pages 157-163

   12. The Role of Nitroarenes in the Mutagenicity of Airborne Particles Indoors and Outdoors

       • Hiroshi Tokiwa, Nobuyuki Sera, Mamiko Kai, Kazumi Horikawa, Yoshinari Ohnishi

       Pages 165-172

4. Complex Mixtures of Genotoxicants in Waters

   1. Characterization of Mutagenic Compounds Formed During Disinfection of Drinking Water

      • Leif Kronberg

      Pages 173-183

   2. Genotoxic and Carcinogenic Properties of Chlorinated Furanones: Important by-Products of Water Chlorination

      • J. R. Meier, A. B. DeAngelo, F. B. Daniel, K. M. Schenck, J. U. Doerger, L. W. Chang et al.

      Pages 185-195

   3. Assessment and Identification of Genotoxic Compounds in Water

      • J. K. Fawell, H. Horth

      Pages 197-214

   4. Methods to Measure Genotoxins in Wastewater: Evaluation with in vivo and in vitro Tests

      • Marten A. van der Gaag, Laury Gauthier, Arie Noordsij, Yves Levi, M. Nicoline Wrisberg

      Pages 215-232

   5. Detection of Genotoxicity in Chlorinated or Ozonated Drinking Water Using an Amphibian Micronucleus Test

      • André Jaylet, Laury Gauthier, Yves Lévi

      Pages 233-247

5. Exposure/Effects Assessment

   1. The Significance of Mutagenicity as a Criterion in Ecotoxicological Evaluations

      • W. K. de Raat, G. J. Vink, A. O. Hanstveit

      Pages 249-269

Contained in this volume are the proceedings of the international conference on the "Genetic Toxicology of Complex Mixtures," held from July 4-7, 1989, in Washington, DC. This meeting was a satellite of the "Fifth International Conference on Environmental Mutagens" and the seventh in a biennial series of conferences on "Short-term Bioassays in the Analysis of Complex Environmental Mixtures. " Our central objective in calling together key researchers from around the world was to extend our knowledge of the application of the methods of genetic toxicology and analytical chemistry in the evaluation of chemical mixtures as they exist in the environment. This conference emphasized the study of genotoxicants in air and water, and the assessment of human exposure and cancer risk. The latest strategies and methodologies for biomonitoring of genotoxicants (including transformation products) were described in the context of the ambient environment. Source character­ ization and source apportionment were discussed as an aid to understand­ ing the origin and relative contribution of various kinds of complex mix­ tures to the ambient environment. Similarly, investigations of genotoxi­ cants found in the indoor environment (sidestream cigarette smoke) and in drinking water (chlorohydroxyfuranones) were given special attention in terms of their potential health impacts. New molecular techniques were described to enable more precise quantitation of internal dose and dose­ to-target tissues. The emphasis of presentations on exposures/effects assessment was on integrated quantitative evaluation of human exposure and potential health effects.

• Furan
• biomonitoring
• cancer
• cancer risk
• chemistry
• drinking water
• environment
• health effects
• research
• toxicology
• ecotoxicology

• US Environmental Protection Agency, Research Triangle Park, USA

  Michael D. Waters, Joellen Lewtas, Martha M. Moore, Stephen Nesnow

• US Environmental Protection Agency, Cincinnati, USA

  F. Bernard Daniel

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