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Tobacco Smoking and Atherosclerosis

Pathogenesis and Cellular Mechanisms

  • Book
  • © 1990

Overview

Editors:
  1. John N. Diana

    1. Tobacco and Health Research Institute, University of Kentucky, Lexington, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 273)

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Table of contents (34 chapters)

  1. Front Matter

    Pages i-x
    Download chapter PDF

  2. Tobacco Smoking and Atherosclerosis: Overview

    1. Tobacco Smoking and Atherosclerosis: Overview

      • John N. Diana
      Pages 1-7

  3. Epidemiologic Studies Linking Smoking and Atherosclerosis

    1. Smoking and the Pathogenesis of Atherosclerosis

      • Henry C. McGill Jr.
      Pages 9-16

    2. Smoking as a Predictor of Atherosclerosis in the Honolulu Heart Program

      • Dwayne Reed, Ellen Marcus, Takuji Hayashi
      Pages 17-25

    3. Cigarette Smoking as a Risk Factor for Coronary Artery Disease

      • William S. Weintraub
      Pages 27-37

    4. Cigarette Smoking and Extracranial Carotid Atherosclerosis

      • Grethe S. Tell, George Howard, Gregory W. Evans, Michael L. Smith, William M. McKinney, James F. Toole
      Pages 39-49

  4. Effect of Cigarette Smoking on Vascular Endothelial Cells

    1. Smoking, Catecholamines and their Effects on Endothelial Cell Integrity

      • Göran Bondjer, Göran Hansson, Gun Olsson, Knut Pettersson
      Pages 51-59

    2. Cigarette Smoking and Endothelial Injury: A Review

      • R. Michael Pittilo
      Pages 61-78

    3. The Effects of Nicotine on Aortic Endothelial Cell Turnover and Ultrastructure

      • Matthew Zimmerman, John K. McGeachie
      Pages 79-88

    4. Ultrastructural Events Associated with Endothelial Cell Changes During the Initiation and Early Progression of Atherosclerosis

      • Richard G. Taylor, W. Gray Jerome, Jon C. Lewis
      Pages 89-93

    5. The Effect of Cigarette Smoke, Nicotine and Carbon Monoxide on Arterial Wall Permeability and Arterial Wall Uptake of 125 I-Fibrinogen

      • D. R. Allen, N. L. Browse
      Pages 95-106

    6. Some Acute Effects of Smoking on Endothelial Cells and Platelets

      • James W. Davis
      Pages 107-118

  5. Effect of Cigarette Smoking on Platelets, Vascular Tissue and Eicosanoids

    1. Platelets in the Pathogenesis of Atherosclerosis

      • Wolfgang Siess
      Pages 119-127

    2. Smoking, Platelet Reactivity and Fibrinogen

      • Jack Kutti
      Pages 129-134

    3. Vascular and Platelet Eicosanoids, Smoking and Atherosclerosis

      • J. Y. Jeremy, D. P. Mikhailidis
      Pages 135-146

    4. Macrophage Influence on Smooth Muscle Phenotype in Atherogenesis

      • Gordon R. Campbell, Julie H. Campbell
      Pages 147-159

    5. Cigarette Smoking and Platelet Function: Relation to Nicotine, Carbon Monoxide and Saturated Fat

      • Serge Renaud
      Pages 161-171

    6. Atherosclerosis Alters the Response to Activated Platelets and Leukocytes

      • Donald D. Heistad, J. Antonio Lopez, Mark L. Armstrong
      Pages 173-180

    7. Platelets in Chronic Smokers Show a Hyperactive Response in Vitro to a Foreign Surface

      • Paul D. Stein, Jan Rival, Jeanne M. Riddle
      Pages 181-187

    8. Platelet — Vessel Wall Interactions in Individuals who Smoke Cigarettes

      • John J. Murray, Jacek Nowak, John A. Oates, Garret A. FitzGerald
      Pages 189-198
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Keywords

About this book

Atherosclerosis is the principal underlying cause of cardiovascular and cerebrovascular disease in people of the Western world. Cigarette smoking has been implicated in both the initiation and exacerbation of the atherosclerotic process. Data to support this implication derives primarily from epidemiologic studies where the relationship between the incidence of atherosclerosis in people who smoke cigarettes has been shown to have a strong correlation. There are few well established explanations for this phenomenon, and basic molecular, biochemical, and cellular mechanisms associated with smoking and the development of atherosclerosis remain both undefined and virtually unexplored. Even the epidemiologic correlation between cigarette smoking and the development of atherosclerosis needs further critical studies. It is known that individuals who do not smoke cigarettes develop athero­ sclerosis and it is also known that in people who smoke but have normal or low blood cholesterol/lipoprotein levels, the incidence of development of atherosclerosis is no different from that which is found in a non­ smoking population. Answers which explain such observations must address fundamental biological mechanisms. Toward this end, the purpose of this volume is to assemble, in a single publication, information which will address the questions; what basic cellular and/or molecular mechanisms are associated with the development of atherosclerosis and how does cigarette smoking influence such mechanisms to initiate or exacerbate the atherosclerotic process? Clearly, the development of atherosclerosis is a complex, multifactorial biological event.

Editors and Affiliations

  • Tobacco and Health Research Institute, University of Kentucky, Lexington, USA

    John N. Diana

Bibliographic Information

  • Book Title: Tobacco Smoking and Atherosclerosis

  • Book Subtitle: Pathogenesis and Cellular Mechanisms

  • Editors: John N. Diana

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5829-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1990

  • Softcover ISBN: 978-1-4684-5831-2Published: 19 March 2012

  • eBook ISBN: 978-1-4684-5829-9Published: 13 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 404

  • Topics: Cardiology, Pharmacology/Toxicology, Biochemistry, general

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