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Advances in Experimental Medicine and Biology

Coronaviruses and their Diseases

Editors: Cavanagh, David, Brown, T. David K. (Eds.)

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  • ISBN 978-1-4684-5823-7
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Softcover $159.99
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About this book

Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.

Table of contents (43 chapters)

  • Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes

    Cavanagh, D. (et al.)

    Pages 1-2

  • Background Paper Functions of Coronavirus Glycoproteins

    Holmes, Kathryn V. (et al.)

    Pages 5-7

  • Biosynthesis and Function of the Coronavirus Spike Protein

    Vennema, H. (et al.)

    Pages 9-19

  • Functional Analysis of the Coronavirus MHV-JHM Surface Glycoproteins in Vaccinia Virus Recombinants

    Pfleiderer, M. (et al.)

    Pages 21-31

  • Role of pH in Syncytium Induction and Genome Uncoating of Avian Infectious Bronchitis Coronavirus (IBV)

    Li, D. (et al.)

    Pages 33-36

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-4684-5823-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-1-4684-5825-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Coronaviruses and their Diseases
Editors
  • David Cavanagh
  • T. David K. Brown
Series Title
Advances in Experimental Medicine and Biology
Series Volume
276
Copyright
1990
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5823-7
DOI
10.1007/978-1-4684-5823-7
Softcover ISBN
978-1-4684-5825-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
676
Topics