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Coronaviruses and their Diseases

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. David Cavanagh

    1. AFRC Institute for Animal Health, Huntingdon, UK

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    You can also search for this editor in PubMed   Google Scholar

  2. T. David K. Brown

    1. Department of Pathology, University of Cambridge, UK

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 276)

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Table of contents (89 papers)

  1. Front Matter

    Pages i-xv
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  2. Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes

    1. Revised Nomenclature for Coronavirus Structural Proteins, mRNAs and Genes

      • D. Cavanagh, D. Brian, L. Enjuanes, K. Holmes, M. Lai, H. Laude et al.
      Pages 1-2

  3. The Spike (S) Glycoprotein

    1. Front Matter

      Pages 3-3
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    2. Background Paper Functions of Coronavirus Glycoproteins

      • Kathryn V. Holmes, Richard K. Williams
      Pages 5-7

    3. Biosynthesis and Function of the Coronavirus Spike Protein

      • H. Vennema, P. J. M. Rottier, L. Heijnen, G. J. Godeke, M. C. Horzinek, W. J. M. Spaan
      Pages 9-19

    4. Functional Analysis of the Coronavirus MHV-JHM Surface Glycoproteins in Vaccinia Virus Recombinants

      • M. Pfleiderer, E. Routledge, S. G. Siddell
      Pages 21-31

    5. Role of pH in Syncytium Induction and Genome Uncoating of Avian Infectious Bronchitis Coronavirus (IBV)

      • D. Li, D. Cavanagh
      Pages 33-36

    6. Is the 110K Glycoprotein the Only Receptor for MHV and Does Its Expression Determine Species Specificity?

      • Kathryn V. Holmes, Richard K. Williams, Christine B. Cardellichio, Susan R. Compton, Charles B. Stephensen, Stuart W. Snyder et al.
      Pages 37-44

    7. MHV-Resistant SJL/J Mice Express a Non-Functional Homolog to the MHV Receptor Glycoprotein

      • Richard K. Williams, Stuart W. Snyder, Kathryn V. Holmes
      Pages 45-50

    8. Fc Receptor-Like Activity of Mouse Hepatitis Virus E2 Glycoprotein

      • Emilia L. Oleszak, Julian L. Leibowitz
      Pages 51-58

    9. Mouse Fibroblast Mutants Selected for Survival Against Mouse Hepatitis Virus Infection Show Increased Resistance to Infection and Virus-Induced Cell Fusion

      • M. Daya, F. Wong, M. Cervin, G. Evans, H. Vennema, W. J. M. Spaan et al.
      Pages 59-66

    10. On the Membrane Cytopathology of Mouse Hepatitis Virus Infection as Probed by a Semi-Permeable Translation-Inhibiting Drug

      • G. Macintyre, C. Kooi, F. Wong, R. Anderson
      Pages 67-72

    11. Molecular Characterization of the 229E Strain of Human Coronavirus

      • Nathalie Arpin, Pierre J. Talbot
      Pages 73-80

    12. Sequence Analysis of the 3′ End (8740 Nucleotides) of BECV Genome; Comparison with Homologous MHV Nucleotide Sequence

      • Pascal Boireau, Nathalie Woloszyn, Catherine Crucière, Ericka Savoysky, Jacques Laporte
      Pages 81-88

  4. The Haemagglutinin-Esterase (HE) and Membrane (M) Glycoproteins

    1. Front Matter

      Pages 89-89
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    2. Background Paper Coronavirus M and HE: Two Peculiar Glycoproteins

      • Peter J. M. Rottier
      Pages 91-94

    3. Structure and Expression of the Bovine Coronavirus Hemagglutinin Protein

      • Thomas E. Kienzle, Sushma Abraham, Brenda G. Hogue, David A. Brian
      Pages 95-102

    4. The Haemagglutinin of Bovine Coronavirus Exhibits Significant Similarity to the Haemagglutinin of Type C Influenza Virus

      • Michael D. Parker, Graham J. Cox, Dongwan Yoo, David R. Fitzpatrick, Lorne A. Babiuk
      Pages 103-108

    5. Isolation and Characterization of the Acetylesterase of Hemagglutinating Encephalomyelitis Virus (HEV)

      • Beate Schultze, R. Günter Heβ, Rudolf Rott, Hans-Dieter Klenk, Georg Herrler
      Pages 109-113

    6. Differential Reactivity of Bovine Coronavirus (BCV) and Influenza C Virus with N-Acetyl-9-O-Acetylneuraminic Acid (NEU5,9AC2)-Containing Receptors

      • Beate Schultze, Hans-Jürgen Groβ, Hans-Dieter Klenk, Reinhard Brossmer, Georg Herrler
      Pages 115-119
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Keywords

About this book

Interest in the coronaviruses has never been greater. Their economic impact is considerable as they infect humans, livestock, poultry and companion animals. Murine hepatitis virus (MHV) infection of the mouse and rat central nervous systems are the subject of intense study; these investigations are providing insights into the potential role of viruses in human neurological diseases and, more generally, into mechanisms causing neurological damage. The single-stranded, positive-sense RNA genomes of two species of these enveloped viruses (IBV and MHV) have been cloned completely and one of them (lBV) sequenced in its entirety, revealing a genome size of some 27000 nucleotides. This has made possible more incisive investigations into the nature of those polypeptides, encoded by more than half of the genome, which are likely to contribute, in the main, to RNA polymerase/replicase activity. Intriguingly, ribosomal frameshifting is exhibited within the mRNA coding for these polypeptides. The cloning/sequencing phase of coronavirology for which the 1980's will be partly remembered, has provided a sound framework for furthex: studies of the virus structural proteins and also some provocative insights relevant to these studies. The large spike glycoprotein(s), responsible for membrane fusion and bearing important antigenic sites, varies amazingly in length and composition both within as well as between coronavirus species. Receptors on host cells have been identified. The integral membrane glycoprotein (M) has been shown to use internal hydrophobic sequences to direct translocation within membranes.

Editors and Affiliations

  • AFRC Institute for Animal Health, Huntingdon, UK

    David Cavanagh

  • Department of Pathology, University of Cambridge, UK

    T. David K. Brown

Bibliographic Information

  • Book Title: Coronaviruses and their Diseases

  • Editors: David Cavanagh, T. David K. Brown

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5823-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1990

  • Softcover ISBN: 978-1-4684-5825-1Published: 25 November 2012

  • eBook ISBN: 978-1-4684-5823-7Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: 676

  • Topics: Veterinary Medicine/Veterinary Science

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