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Advances in Experimental Medicine and Biology

Antioxidants in Therapy and Preventive Medicine

Editors: Emerit, Ingrid, Packer, Lester, Auclair, Christian (Eds.)

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  • ISBN 978-1-4684-5730-8
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About this book

Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.

Table of contents (49 chapters)

  • Extracellular-Superoxide Dismutase, Distribution in the Body and Therapeutic Applications

    Marklund, Stefan L. (et al.)

    Pages 1-4

  • Targeting Sod by Gene and Protein Engineering and Inhibition of Oxidative Stress in Various Diseases

    Inoue, Masayasu (et al.)

    Pages 5-12

  • The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury

    Grabitz, K. (et al.)

    Pages 13-16

  • Sod in Rat Models of Shock and Organ Failure

    Redl, Heinz (et al.)

    Pages 17-27

  • The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase

    Fontecave, Marc (et al.)

    Pages 29-35

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-4684-5730-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-1-4684-5732-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Antioxidants in Therapy and Preventive Medicine
Editors
  • Ingrid Emerit
  • Lester Packer
  • Christian Auclair
Series Title
Advances in Experimental Medicine and Biology
Series Volume
264
Copyright
1990
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5730-8
DOI
10.1007/978-1-4684-5730-8
Softcover ISBN
978-1-4684-5732-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
608
Topics