Antioxidants in Therapy and Preventive Medicine

1. Front Matter

   Pages i-xiii

   PDF

2. Superoxide Dismutase

   1. Extracellular-Superoxide Dismutase, Distribution in the Body and Therapeutic Applications

      • Stefan L. Marklund, Kurt Karlsson

      Pages 1-4

   2. Targeting Sod by Gene and Protein Engineering and Inhibition of Oxidative Stress in Various Diseases

      • Masayasu Inoue, Nobukazu Watanabe

      Pages 5-12

   3. The Role of Superoxide Dismutase (SOD) in Preventing Postischemic Spinal Cord Injury

      • K. Grabitz, E. Freye, R. Prior, R. Kolvenbach, W. Sandmann

      Pages 13-16

   4. Sod in Rat Models of Shock and Organ Failure

      • Heinz Redl, Camille Lieners, Soheyl Bahrami, Günther Schlag, Ignaz P. T. van Bebber, R. Jan A. Goris

      Pages 17-27

   5. The Protective Role of Superoxide Dismutase During Activation of Ribonucleotide Reductase

      • Marc Fontecave, Peter Reichard

      Pages 29-35

   6. Effect of Superoxide Dismutase on the Autoxidation of Hydroquinones Formed During DT-Diaphorase Catalysis and Glutathione Nucleophilic Addition

      • Enrique Cadenas, Lars Ernster

      Pages 37-44

3. Copper Complexes and Other Sod Mimicks

   1. Superoxide Scavengers and SOD or SOD Mimics

      • Gidon Czapski, Sara Goldstein

      Pages 45-50

   2. Reactivity of Active Centre Analogues of Cu2Zn2Superoxide Dismutase

      • Ulrich Weser, Ralf Miesel, Margot Linss

      Pages 51-57

   3. SOD Mimicking Properties of Copper (II) Complexes: Health Side Effects

      • Gérard Lapluye

      Pages 59-68

   4. Radiation Recovery Agents: Cu(II), Mn(II), Zn(II), OR Fe(III) 3,5-Diisopropylsalicylate Complexes Facilitate Recovery from Ionizing Radiation Induced Radical Mediated Tissue Damage

      • John J. R. Sorenson, Lee S. F. Soderberg, Max L. Baker, John B. Barnett, Louis W. Chang, Hamid Salari et al.

      Pages 69-77

   5. Effects of Glycyl-Histidyl-Lysyl Chelated Cu(II) on Ferritin Dependent Lipid Peroxidation

      • D. M. Miller, D. DeSilva, L. Pickart, S. D. Aust

      Pages 79-84

   6. SOD-Like Activity of 5-Membered Ring Nitroxide Spin Labels

      • Amram Samuni, Ahn Min, C. Murali Krishna, James B. Mitchell, Angelo Russo

      Pages 85-92

4. Antioxidant Vitamins

   1. Vitamin E in Biological Systems

      • Lester Packer, Sharon Landvik

      Pages 93-103

   2. The Role of Vitamin E in the Hepatotoxicity by Glutathione Depleting Agents

      • Alessandro F. Casini, Emilia Maellaro, Barbara Del Bello, Mario Comporti

      Pages 105-110

   3. Regulation of Lipid Peroxidation by Glutathione and Lipoic Acid: Involvement of Liver Microsomal Vitamin E Free Radical Reductase

      • Aalt Bast, Guido R. M. M. Haenen

      Pages 111-116

   4. Quenching of Singlet Molecular Oxygen by Tocopherols

      • Stephan Kaiser, Paolo Di Mascio, Michael E. Murphy, Helmut Sies

      Pages 117-124

   5. Antioxidant Properties of Vitamin E and Membrane Permeability in Human Fibroblast Cultures

      • Marc Conti, Martine Couturier, Frédérique Lemonnier, Alain Lemonnier

      Pages 125-128

   6. Vitamin E and Tumor Growth

      • Mariette Gerber, Sylvia Richardson, François Favier, André Crastes De Paulet

      Pages 129-132

   7. Abnormal Susceptibility to Lipid Peroxidation of Plasma LDL and Its Prevention by α-Tocopherol During Experimental Cholestasis in the Rat

      • L. G. Alcindor, H. Antebi, M. Fadel-Khadra, M-C. Piot, Y. Giudicelli, R. Nordmann

      Pages 133-137

Twenty years ago, the enzyme superoxide dismutase which uses the superoxide radical anion as its specific substrate was reported. With this discovery was born a new scientific field, in which oxygen, necessary for aerobi c 1 ife on thi s planet, had to be cons i dered also in terms of its toxicity and stresses. This stimulated the search for knowledge of active oxygen species in biology and medicine. Superoxide and other reactive oxygen species are now implicated in many disease processes. Major advances have been achieved during these past years with respect to free radical generation and mechanisms of free radical action in causing tissue injury. In parallel, the possibil ity of influencing free radical related disease processes by antioxidant treatment was studied in various in vitro and in vivo systems. This was the unique theme of a conference organized in Paris by the Society for Free Radical Research (December 9-10, 1988) which brought together experts from basic sciences and clinicians in order to evaluate the current status of antioxidant therapy. The conference emphasized fundamental processes in antioxidant action. Among the major topics were superoxide dismutase (SOD) and low molecular weight substances with such activity, called SOD mimics. Other antioxidant enzymes were also considered. Antioxidant vitamins, in particular vitamins E and C, other naturally occurri ng antioxidants and vari ous synthet i c antioxidants were included in the presentations as there is now a rapidly developing series of compounds with potentially interesting clinical applications.

• antioxidant
• biology
• enzyme
• enzymes
• preventive medicine
• research
• toxicity
• Ultrasonography

• Centre National de la Recherche Scientifique, University of Paris, Paris, France

  Ingrid Emerit

• Groupe de Recherche Radicaux Libres, Institut Biomédical des Cordeliers, Paris, France

  Ingrid Emerit

• Dept. of Physiology Anatomy, University of California, Berkeley, Berkeley, USA

  Lester Packer

• Institut Gustave-Roussy, Villejuif, France

  Christian Auclair

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