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Advances in Experimental Medicine and Biology

Purine and Pyrimidine Metabolism in Man VI

Part A: Clinical and Molecular Biology

Editors: Mikanagi, K. (Ed.)

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About this book

These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.

Table of contents (49 chapters)

  • NAD Synthesis by Erythrocytes in Phosphoribosylpyrophosphate Synthetase (PRPPs) Superactivity

    Micheli, Vanna (et al.)

    Pages 1-7

  • Increased Purine Nucleotide Degradation in the Central Nervous System (CNS) in PRPP Synthetase Superactivity

    Jiménez, Manuel L. (et al.)

    Pages 9-13

  • Neurodevelopmental Impairment and Deranged PRPP and Purine Nucleotide Synthesis in Inherited Superactivity of PRPP Synthetase

    Becker, Michael A. (et al.)

    Pages 15-22

  • Studies of Mutant Human Adenylosuccinate Lyase

    Barshop, Bruce A. (et al.)

    Pages 23-30

  • Deficiency of AMP Deaminase in Human Erythrocytes

    Żydowo, M. M. (et al.)

    Pages 31-34

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-4684-5673-8
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-1-4684-5675-2
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Purine and Pyrimidine Metabolism in Man VI
Book Subtitle
Part A: Clinical and Molecular Biology
Editors
  • K. Mikanagi
Series Title
Advances in Experimental Medicine and Biology
Series Volume
253A
Copyright
1989
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5673-8
DOI
10.1007/978-1-4684-5673-8
Softcover ISBN
978-1-4684-5675-2
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XIII, 560
Topics