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Purine and Pyrimidine Metabolism in Man VI

Part A: Clinical and Molecular Biology

  • Book
  • © 1989

Overview

Editors:
  1. Kiyonobu Mikanagi

    1. Mikanagi Gotanda Hospital, Tokyo, Japan

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  2. Kusuki Nishioka

    1. Tokyo Women’s Medical College, Tokyo, Japan

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  3. William N. Kelley

    1. University of Michigan Medical Center, Ann Arbor, USA

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 253A)

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Table of contents (89 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Human Diseases and Enzyme Abnormalities

    1. NAD Synthesis by Erythrocytes in Phosphoribosylpyrophosphate Synthetase (PRPPs) Superactivity

      • Vanna Micheli, H. Anne Simmonds
      Pages 1-7

    2. Increased Purine Nucleotide Degradation in the Central Nervous System (CNS) in PRPP Synthetase Superactivity

      • Manuel L. Jiménez, Juan G. Puig, Felícitas A. Mateos, Teresa H. Ramos, Juan S. Melián, Victor G. Nieto et al.
      Pages 9-13

    3. Neurodevelopmental Impairment and Deranged PRPP and Purine Nucleotide Synthesis in Inherited Superactivity of PRPP Synthetase

      • Michael A. Becker, Juan G. Puig, Felicitas A. Mateos, Manuel L. Jimenez, Mitchel Kim, H. Anne Simnonds
      Pages 15-22

    4. Studies of Mutant Human Adenylosuccinate Lyase

      • Bruce A. Barshop, Arthur S. Alberts, Paul K. Laikind, Harry E. Gruber
      Pages 23-30

    5. Deficiency of AMP Deaminase in Human Erythrocytes

      • M. M. Żydowo, J. Purzycka-Preis, N. Ogasawara
      Pages 31-34

    6. Erythrocyte Adenine PRPP Availability in Two Types of APRT Deficiency Using Silicon Oil Method

      • Fujio Takeuchi, Naoyuki Kamatani, Yutaro Nishida, Terumasa Miyamoto
      Pages 35-41

    7. Human Adenine Phosphoribosyltransferase (APRT) Deficiency: Single Mutant Allele Common to the Japanese

      • Yuji Hidaka, Susan A. Tarle, Naoyuki Kamatani, William N. Kelley, Thomas D. Palella
      Pages 43-49

    8. Diagnosis of Genotypes for Adenine Phosphoribosyltransferase (APRT) Deficiency

      • Naoyuki Kamatani, Shoko Kuroshima, Chihiro Terai, Masayuki Hakoda, Kusuki Nishioka, Kiyonobu Mikanagi
      Pages 51-58

    9. High-Performance Liquid Chromatographic Method for Simultaneous Screening of the Deficiencies of APRT and HPRT

      • Toshihiro Nishina, Ryozo Sakuma, Tsukasa Kojima, Motoshi Kiyamura, Naoyuki Kamatani, Kusuki Nishioka
      Pages 59-65

    10. Guanine Nucleotide Metabolism in Red Blood Cells: The Metabolic Basis for GTP Depletion in HGPRT and PNP Deficiency

      • Y. Sidi, I. Gelvan, S. Brosh, J. Pinkhas, O. Sperling
      Pages 67-71

    11. Clinico-Biochemical and Molecular Studies of Purine Nucleoside Phosphorylase Deficiency

      • Takeshi Sakiyama, Munenori Iwase, Kenichi Horinouchi, Akira Akatsuka, Yasuyoshi Yoshida, Takanobu Kikuchi et al.
      Pages 73-79

    12. ATP-Dependent Mineralization of Hyaline Articular Cartilage Matrix Vesicles

      • Robert L. Wortmann, Majeedul Chowdhury, John W. Rachow
      Pages 81-85

    13. Hereditary Xanthine Oxidase Deficiency Consisting of at least Two Subgroups

      • Kazuya Higashino, Tetsuya Yamamoto, Toshikazu Hada, Norio Kono, Masanori Kawachi, Masahisa Nanahoshi et al.
      Pages 87-91

    14. Family Study of Hereditary Xanthinuria — Decreased Duodenal Xanthine Oxidase Activity and Increased Urinary Excretion of Xanthine and Hypoxanthine in Heterozgotes

      • Masanori Kawachi, Norio Kono, Ikuo Mineo, Naoko Hara, Seiichi Himeno, Yuya Yamada et al.
      Pages 93-96

    15. Further Evidence for a ‘New’ Purine Defect, Inosine Triphosphate (ITP) Pyrophosphohydrolase Deficiency

      • H. Anne Simmonds, Vanna Micheli, John A. Duley, Lynette D. Fairbanks, David A. Hopkinson, Roland J. Levinsky
      Pages 97-102

    16. ITP-Pyrophosphohydrolase and Purine Metabolism in Human Erythrocytes

      • Geert van Waeg, Frank Niklasson, Åke Ericson, Carl-Henric de Verdier
      Pages 103-110

    17. Comparative Study of Thymine and Uracil Metabolism in Healthy Persons and in a Patient with Dihydropyrimidine Dehydrogenase Deficiency

      • Albert H. van Gennip, Nico G. Abeling, Lida Elzinga-Zoetekouw, Liny G. Scholten, Arno van Cruchten, Henk D. Bakker
      Pages 111-118

    18. A Screening Method for Dihydropyrimidine Dehydrogenase Deficiency with Colorimetric Detection of Urinary Uracil

      • Kazuki Okajima, Takaharu Yamamoto, Mariko Suchi, Yoshiro Wada
      Pages 119-122

    19. Simple Screening Methods for Disorders of Purine Metabolism Using Dried Blood and or Urine Spots on Filter Paper

      • Y. Nishida, F. Takeuchi, T. Miyamoto
      Pages 123-127
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Keywords

About this book

These two volumes contain articles presented at the Vlth International Symposium on Human Purine and Pyrimidine Metabolism held in Hakone, Japan ,July 17 trough 21, 1988. The first meeting of this series of symposia convened in Tel Aviv, Israel, and since then meetings have taken place every three years in various parts of the world. The second meeting was held in Baden, Austria, the third in Madrid, Spain, the fourth in Maastricht, the Netherlands, and fifth in San Diego, California. The Vlth meeting in Hakone marked the first such symposium held in Asia. On occasion of publishing these books, I would like to describe how research in this field has evolved in Japan. Early in the 1950s, I was engaged in clinical practice treating various rheumatic diseases as an orthopedicist, and found that a substantial percentage of our patients had symptoms apparently compatible with gout. During the 1960s, the number of these gouty patients increased, and in the 1970s, research on the pathogenesis of gout was performed on the basis of approximately 2,000 cases of this disease, together with precise epidemiological studies concerning gouty and hyperuricemic individuals. Data derived from the two kinds of study had greatly changed the notion that gout was a rare disease among Japanese. My clinical studies have been succeeded by research at the molecular level on various purine metabolic abnormalities, including not only gout but also other diseases with various symptoms of wide clinical spectra.

Editors and Affiliations

  • Mikanagi Gotanda Hospital, Tokyo, Japan

    Kiyonobu Mikanagi

  • Tokyo Women’s Medical College, Tokyo, Japan

    Kusuki Nishioka

  • University of Michigan Medical Center, Ann Arbor, USA

    William N. Kelley

Bibliographic Information

  • Book Title: Purine and Pyrimidine Metabolism in Man VI

  • Book Subtitle: Part A: Clinical and Molecular Biology

  • Editors: Kiyonobu Mikanagi, Kusuki Nishioka, William N. Kelley

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5673-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1989

  • Softcover ISBN: 978-1-4684-5675-2Published: 17 April 2013

  • eBook ISBN: 978-1-4684-5673-8Published: 06 December 2012

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 560

  • Topics: Biochemistry, general

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