Basic Life Sciences

Oxygen Radicals in Biology and Medicine

Editors: Simic, Michael (Ed.)

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About this book

This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Table of contents (49 chapters)

  • Introduction to Peroxidation and Antioxidation Mechanisms

    Simic, Michael G. (et al.)

    Pages 1-10

  • The Redox Thermodynamics for Dioxygen Species (O2, O 2 - ·, HOO·, HOOH, and HOO-) and Monooxygen Species (O, O-·, ·OH, and -OH) in Water and Aprotic Solvents

    Sawyer, Donald T.

    Pages 11-20

  • Electron Spin Resonance Investigations of Oxygen-Centered Free Radicals in Biological Systems

    Mason, Ronald P. (et al.)

    Pages 21-27

  • Superoxide Chemistry in Non-Aqueous Media

    Frimer, Aryeh A.

    Pages 29-38

  • Peroxy Radicals and Singlet Oxygen (1O2) from the Addition of Superoxide Ion (O 2 - ·) to CCl4, CF3CCl3, PhCCl3, N-BuBr and N-BuCl in Acetonitrile

    Matsumoto, Shigenobu (et al.)

    Pages 39-42

Buy this book

eBook $139.00
price for USA in USD (gross)
  • ISBN 978-1-4684-5568-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $179.99
price for USA in USD
  • ISBN 978-1-4684-5570-0
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Oxygen Radicals in Biology and Medicine
Editors
  • Michael Simic
Series Title
Basic Life Sciences
Series Volume
49
Copyright
1988
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5568-7
DOI
10.1007/978-1-4684-5568-7
Softcover ISBN
978-1-4684-5570-0
Edition Number
1
Number of Pages
XLVIII, 1094
Topics