Steroid Receptors in Health and Disease

1. Front Matter

   Pages i-xi

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2. Introduction and Keynote Address

   1. Front Matter

      Pages 1-1

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   2. Steroid Receptors in Health and Disease

      • Virinder K. Moudgil

      Pages 3-24

   3. Steroid Receptors: A Historical Perspective

      • Jack Gorski

      Pages 25-31

3. Receptor Structure and Molecular Organization

   1. Front Matter

      Pages 33-33

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   2. Intracellular Localization of Steroid Hormone Receptors: Immunocytochemical Analysis

      • Jean-Marie Gasc, Etienne-Emile Baulieu

      Pages 35-45

   3. Immunocytochemistry of Estrogen and Progestin Receptors in the Primate Reproductive Tract

      • Robert M. Brenner, Maryanne C. McClellan, Neal B. West

      Pages 47-70

   4. Structure, Functional Domains and Subcellular Distribution of Glucocorticoid Receptor

      • Jan Carlstedt-Duke, Ann-Charlotte Wikstrom, Jan-Ake Gustafsson

      Pages 71-83

   5. Hormone-Dependent Phosphorylation of the Avian Progesterone Receptor

      • William P. Sullivan, David F. Smith, David O. Toft

      Pages 85-96

4. Receptor Modifications and Hormone Regulation

   1. Front Matter

      Pages 97-97

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   2. Hormone-Dependent and Hormone-Independent Conformational Transitions of the Estrogen Receptor

      • Jeffrey C. Hansen, Jack Gorski

      Pages 99-109

   3. Human Progesterone Receptors A and B: Two Independent, Functional Forms

      • Kathryn B. Horwitz

      Pages 111-117

   4. Androgen Regulation of Gene Expression: Studies of Ornithine Decarboxylase in Murine Kidney

      • Olli A. Janne, Noreen J. Hickok, Mervi Julkunen, Anne Crozat, Leonard Eisenberg, Evie Melanitou

      Pages 119-131

   5. Advances in Uterus Estradiol Receptor Phosphorylation on Tyrosine and Preliminary Evidences That Liver Glucocorticoid Receptor Might Be Phosphorylated on Tyrosine

      • G. Castoria, A. Migliaccio, M. Di Domenico, M. Pagano, A. Rotondi, E. Nola et al.

      Pages 133-148

5. Receptor Gene Structure and Function

   1. Front Matter

      Pages 149-149

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   2. Functional Analysis of the Estrogen and Progesterone Receptors

      • H. Gronemeyer, M. Berry, M. T. Bocquel, J. Eul, S. Green, J. M. Jeltsch et al.

      Pages 151-161

   3. Molecular Determinants of Positive and Negative Regulation by Ligand-Regulated Transcription Factors

      • Michael G. Rosenfeld, Christopher K. Glass, Rodrigo Franco, Stuart Adler, Marian L. Waterman, Xi He

      Pages 163-176

   4. The Mammalian Progesterone Receptor: Cloning, Immunolocalization and Mechanism of Interaction with DNA

      • Jean-Francois Savouret, Hugues Loosfelt, Micheline Misrahi, Michel Atger, Alain Bailly, Martine Perrot-Applanat et al.

      Pages 177-186

   5. Isolation and Sequence of the Human Glucocorticoid Receptor Gene Promoter. Cloning of the Human Androgen Receptor cDNA

      • Manjapra V. Govindan, Marco Burelle, Celine Cantin, Martine Devic, Claude Labrie, Fernand Labrie et al.

      Pages 187-206

6. Biochemical Actions and Antihormones

   1. Front Matter

      Pages 207-207

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During the last two decades, progress in steroid hormone research has resulted in the development of new approaches to contraception as well as diagnosis and treatment of endocrine disorders and cancers. Although significant advances have been made in the purification, characterization, immunochemistry and molecular biology of steroid receptors, the precise molecular mechanism of steroid hormone action has remained obscure. This book captures the detailed presentations made at the first conference on Steroid Receptors in Health and Disease held at Meadow Brook Hall, Oakland University in the fall of 1987. The purpose of this international con­ ference was to facilitate scientific exchange toward a better understand­ ing of the mode of action of steroid hormones. The scientific sessions consisted of poster presentations and state-of-the-art lectures, the latter of which make up this volume. The first chapter is meant to provide the reader with a more general background of the topics covered in the book, as well as to discuss certain theme-related issues that are either not yet well-established or accepted or are in the stage of infancy. It is hoped that this volume will serve as a useful treatise for students and investigators interested in basic and clinical aspects of biological regulation by steroid hormones. A task of this magnitude could not have been undertaken without the encouragement, advice and continued generous assistance of the members of the scientific committee. I am gratefully indebted to Drs.

• biology
• cancer
• chemistry
• contraception
• development
• diagnosis
• estrogen action
• estrogen receptor
• health
• hormone
• hormone receptors
• hormones
• molecular biology
• steroid
• treatment
• diabetes

• Oakland University, Rochester, USA

  Virinder K. Moudgil

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