Basic Life Sciences

Phenotypic Variation in Populations

Relevance to Risk Assessment

Editors: Woodhead, Avril (Ed.)

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About this book

The human race has enormous he terogenei ty, founded on genetic and environmental sources. Variability, therefore, is a vital dimension in any consideration of human risk assessment. In the estimation of risks, current methods of extrapolation based upon converting the response of a median man are inadequate, as they ignore phenotypic variation and there­ fore, susceptible subgroups. There is a growing literature defining the extent of human variation in normal populations; thus, the normal young adult population may have 10-20% known hyperreactors. How far can we ignore human variability in risk assessment? Should we be concerned with susceptible groups, and how can we modify the risk assessment analysis accordingly? The aim of our meeting was to bring together experts from the fields of human epidemiology, toxicology, aging, genetics, carcino­ genesis and teratology, and to provide a forum in which we might assimi­ late knowledge of human heterogeneity as a coherent whole. Since the resolution and obligations of risk assessment, in the last analysis, are a political process, we also involved representatives from the legal field, the unions, and the regulatory agencies. We are most grateful for financial support from the National Institute on Aging; the u. S. Environmental Protection Agency; the U. S. Department of Energy; FDA - National Center for Toxicological Research; The Council for Tobacco Research-USA, Inc; Johnson and Johnson; Merck Sharp and Dohme Research Laboratories; and Associated Universities, Inc. We thank our Symposium Coordinator, Ms.

Table of contents (27 chapters)

Table of contents (27 chapters)

Buy this book

eBook $109.00
price for USA in USD
  • ISBN 978-1-4684-5460-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $149.99
price for USA in USD
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Bibliographic Information

Bibliographic Information
Book Title
Phenotypic Variation in Populations
Book Subtitle
Relevance to Risk Assessment
Editors
  • Avril Woodhead
Series Title
Basic Life Sciences
Series Volume
43
Copyright
1988
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5460-4
DOI
10.1007/978-1-4684-5460-4
Softcover ISBN
978-1-4684-5462-8
Edition Number
1
Number of Pages
X, 305
Number of Illustrations
27 b/w illustrations
Topics