Advances in Experimental Medicine and Biology

Immunobiology of Proteins and Peptides IV

T-Cell Recognition and Antigen Presentation

Authors: Atassi, M.Zouhair, Bachrach, Howard L.

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About this book

This symposium was established in 1976 for the purpose of bringing to­ gether once every two or three years, active investigators in the fore­ front of contemporary immunology, to present their findings and to discuss their significance in the light of current concepts and to identify important new directions of investigation. The founding of the symposium was stimulated by the achievement of major breakthroughs in the under­ standing of the immune recognition of proteins and peptides. We believed that these breakthroughs will lead to the creation of a new generation of peptides which should have enormous potential in biological, therapeutic and basic applications. This anticipated explosion has finally occurred and many applications of these peptides are now being realized. The main symposia topics of the fourth symposium were: T-cell recognition of proteins, structure and function of the T-cell receptor, presentation of protein antigens, recycling and activation of membrane receptor molecules, Ir-gene control of T-cell responses and methods of cell separation. The molecular features recognized by antibodies on proteins were the first immune recognition sites to be local ized and confirmed by synthetic peptides. The complete antigenic structures of several proteins have been defined, and individual antigenic sites have been described on many more proteins. More recently, major breakthroughs have been reported in the immune recognition of proteins by T cells.

Table of contents (27 chapters)

  • The Major Histocompatibility Complex and Protein Recognition by T Lymphocytes

    Klein, Jan

    Pages 1-10

  • Murine Ia Genes: Organization, Polymorphism and Heterogeneity

    Donovan, Kathleen (et al.)

    Pages 11-35

  • Intermediates in Class II HLA Antigen Biosynthesis

    Cresswell, Peter (et al.)

    Pages 37-42

  • Trinitrophenyl Reactive T-Cell Clones in Functional and Molecular Analysis of the HLA-D Region

    Rich, Robert R. (et al.)

    Pages 43-54

  • T-Cells Recognize IA Conformation in the Interaction with Antigen Presenting Cells

    Tse, Harley Y. (et al.)

    Pages 55-63

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5442-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-5444-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Immunobiology of Proteins and Peptides IV
Book Subtitle
T-Cell Recognition and Antigen Presentation
Authors
Series Title
Advances in Experimental Medicine and Biology
Series Volume
225
Copyright
1987
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-5442-0
DOI
10.1007/978-1-4684-5442-0
Softcover ISBN
978-1-4684-5444-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XI, 333
Topics