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Mycobacterium tuberculosis

Interactions with the Immune System

  • Book
  • © 1988

Overview

Editors:
  1. Mauro Bendinelli

    1. University of Pisa, Pisa, Italy

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    You can also search for this editor in PubMed   Google Scholar

  2. Herman Friedman

    1. University of South Florida, Tampa, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Infectious Agents and Pathogenesis (IAPA)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xxi
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  2. Mycobacterial Antigens

    • L. F. Affronti
    Pages 1-37

  3. Role of Adjuvant and Immunogenic Moieties of M. tuberculosis in Pathogenicity

    • Kazuyuki Kato, Ken-Ichi Yamamoto
    Pages 39-58

  4. Genetic Background of the Host and Expression of Natural Resistance and Acquired Immunity to M. tuberculosis

    • Ellen Buschman, Emil Skamene
    Pages 59-79

  5. Immune Response to Mycobacteria

    • Antonio Scordamaglia, Marcello Bagnasco, Giorgio Walter Canonica
    Pages 81-98

  6. The Tubercle Bacillus—Human Macrophage Relationship Studied In Vitro

    • Alfred J. Crowle
    Pages 99-135

  7. Regulation and Pharmacology of Granulomatous Inflammation

    • Vernon L. Moore
    Pages 137-150

  8. Cytolytic Cells in M. tuberculosis Infections

    • Stefan H. E. Kaufmann, Gennaro De Libero
    Pages 151-170

  9. Anergy and Other Immunologic Perturbances in Mycobacterial Infections

    • P. H. Lagrange, B. Hurtrel
    Pages 171-205

  10. Anergy in Experimental Mouse Models of Mycobacterial Infection

    • Ian M. Orme
    Pages 207-225

  11. Suppressor Cells in Mycobacterial Infections

    • Reiko M. Nakamura, Tohru Tokunaga
    Pages 227-241

  12. Immunoregulatory Function of Mononuclear Phagocytes in Tuberculosis

    • Jerrold J. Ellner
    Pages 243-262

  13. Role of B Lymphocytes and Antibodies in the Regulation of Cell-Mediated Immune Reactions to BCG in Mice

    • Mario Campa, Paola Marelli, Gioia Benedettini
    Pages 263-275

  14. Polyclonal Lymphocyte Activation by M. tuberculosis and Its Products

    • Barnet M. Sultzer
    Pages 277-304

  15. Mechanisms of Toxicity of Tubercle Bacilli for Macrophages

    • Quentin N. Myrvik, Eva S. Leake, Mayer B. Goren
    Pages 305-325

  16. Mycobacterium-Induced Suppressor Cells and Their Clinical Importance

    • S. Orbach-Arbouys
    Pages 327-340

  17. The Protective Effects of BCG Vaccination against Tuberculosis

    • Donald W. Smith, Ernst H. Wiegeshaus, Mark L. Edwards
    Pages 341-370

  18. Changing Faces of Clinical Tuberculosis

    • William W. Stead, Asim K. Dutt
    Pages 371-388

  19. Mycobacterium avium-Complex Infections and Immunodeficiency

    • Frank M. Collins
    Pages 389-414

  20. Back Matter

    Pages 415-426
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Keywords

About this book

Tuberculosis once again occupies a special position in the areas of infec­ tious diseases and microbiology. This disease has been important to mankind since even before biblical times. Tuberculosis has been a major cause of morbidity and mortality in humans, especially in highly ur­ banized Europe, until a few decades ago. Indeed, this disease became a center of many novels, plays, and operas, since it appeared to be quite popular to have the heroine dying of "consumption. " Most importantly, tuberculosis also became the focus of attention for many investigations during the 19th and even the 20th centuries. Major advances were made in the areas of isolation and identification of M. tuberculosis and related microorganisms. The discovery, by Robert Koch, that tuberculosis was caused by an infectious agent revolutionized our thinking about dis­ eases. Koch's postulates were developed with tuberculosis in mind and became a focal point for many advances in microbiology and medicine. Studies with mycobacteria as a central focus have also led to revolu­ tionary new concepts about immunology in general. Koch himself showed that those exposed to M. tuberculosis develop a skin hypersen­ sitivity or allergy to the microorganism's antigens, an observation which was the starting point for many important developments. Indeed, imme­ diate-type hypersensitivity and atopic or IgE-mediated allergy were de­ fined in relation to the delayed-type cutaneous hypersensitivity evi­ denced with the tubercle bacillus.

Editors and Affiliations

  • University of Pisa, Pisa, Italy

    Mauro Bendinelli

  • University of South Florida, Tampa, USA

    Herman Friedman

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