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Amyotrophic Lateral Sclerosis

Therapeutic, Psychological, and Research Aspects

  • Book
  • © 1987

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Editors:
  1. V. Cosi

    1. University of Pavia, Pavia, Italy

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  2. Ann C. Kato

    1. University Medical Center, Geneva, Switzerland

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  3. W. Parlette

    1. ALS/MND Research Foundation, Zurich, Switzerland

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  4. P. Pinelli

    1. University of Milan, Milan, Italy

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  5. M. Poloni

    1. University of Milan, Milan, Italy

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Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 209)

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Table of contents (53 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Basic Research in ALS

    1. Front Matter

      Pages 1-1
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    2. Deficient Repair of Alkylation Damage of DNA in Alzheimer’s Disease and Amyotrophic Lateral Sclerosis Cells

      • W. G. Bradley, S. H. Robison, R. Tandan
      Pages 3-6

    3. Immunoglobulin-Mediated Cytotoxic Effect of ALS-Plasma Towards Erythrocytes: Reflexion of a Pathogenetic Mechanism?

      • S. Conradi, L.-O. Ronnevi
      Pages 7-13

    4. Differentiation of Human Muscle Cells in the Presence of Neuronal Conditioned Medium (NCM), Nerve Growth Factor (NGF) and Spinal Cord Cells (SC)

      • C. Delaporte, B. Dautréaux
      Pages 15-17

    5. GM2 Gangliosidosis with a Motor Neuron Disease Phenotype: Clinical Heterogeneity of Hexosaminidase Deficiency Disease

      • A. Federico
      Pages 19-23

    6. Addendum

      • V. Cosi, Ann C. Kato, W. Parlette, P. Pinelli, M. Poloni
      Pages 23-23

    7. Proteases, Their Inhibitors and the Extracellular Matrix: Factors in Nerve-Muscle Development and Maintenance

      • B. W. Festoff
      Pages 25-39

    8. The Role of Axoplasmic Transport in the Restoration of Synaptic Transmission and in the Process of Sprouting During Nerve Regeneration

      • A. Gorio
      Pages 41-49

    9. Purification of a Survival Factor for Spinal Neurons from Mouse Salivary Gland

      • M. E. Gurney, B. R. Apatoff, S. P. Heinrich
      Pages 51-58

    10. Neurite-Promoting Factors for Spinal Neurons: Their Possible Importance for the Understanding of Amyotrophic Lateral Sclerosis and the Spinal Muscular Atrophies

      • C. E. Henderson
      Pages 59-64

    11. Human Spinal Cord Neurons in Culture as a Tool to Study Amyotrophic Lateral Sclerosis

      • A. C. Kato, L. Erkman, G. Touzeau
      Pages 65-70

    12. Autoimmune Involvement in Motor Neurone Disease

      • J. Aspin, R. Harrison, A. Jehanli, G. G. Lunt
      Pages 71-73

    13. Cytotoxicity of Serum from Amyotrophic Lateral Sclerosis Patients on Spinal Cord Cells in Culture

      • I. Maher, A. Pouplard-Barthelaix, J. Emile
      Pages 75-77

    14. ALS Cerebrospinal Fluid Enhances Human Foetal Astroglial Cell Proliferation in Vitro

      • V. Silani, A. Pizzuti, L. M. Redaelli, R. Bassani, I. R. Causarano, M. Buscaglia et al.
      Pages 79-81

    15. The Electromyographic, Physiopathogenetic Evaluation of Amyotrophic Lateral Sclerosis

      • P. Pinelli
      Pages 83-87

    16. The Pathogenetic Role of Metals in Motor Neuron Disease — The Participation of Aluminum

      • Y. Yase
      Pages 89-96

  3. Diagnostic Tools

    1. Front Matter

      Pages 97-97
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    2. The Syndromic Nature of Amyotrophic Lateral Sclerosis

      • B. M. Patten
      Pages 99-107

    3. Familial ALS: Clinical, Genetic and Morphological Features

      • M. Armani, S. Pierobon-Bormioli, M. L. Mostacciuolo, M. Cacciavillani, M. A. Cassol, R. M. Candeago et al.
      Pages 109-110
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Keywords

About this book

An International Conference on "Therapeutic. Psychological and Research Aspects of Amyotrophic Lateral Sclerosis" was held in Varese. Italy from the 27th to the 31st March 1985. Health care professionals. scientists. patients and their families from twenty countries around the world participated in this meeting. The objectives of the Varese conference were the following: a. To provide a forum for the proponents of the various paths of research into ALS. b. To correlate the useful therapies employed regionally. for the purpose of developing a common guide for patients, families, and supporting professionals. c. To encourage self-examination by the health care professionals into the psychological barriers imposed by a diagnosis of terminal illness for which there is no known cause or cure. Not surprisingly, there were no announcements of "breakthroughs" or "miracle cures", which are nonetheless hoped for in the confrontation of a disease such as ALS. It is fair to say, however, that Varese provided the context for a thorough review of what is known about ALS and we hope that the papers will renew some of the enthusiasm which has characterized this conference. The book contains six sections: Basic Research Aspects, Diagnostic Tools, Clinical Management, Therapeutic Trials, Psychological Aspects and the Epidemiology of ALS. Certain aspects, such as pathological studies and animal models, have not been covered; these subjects were partially treated during the informal sessions. Nevertheless, the large number of papers bears evidence to the growing interest in ALS and to the success of the Varese meeting.

Editors and Affiliations

  • University of Pavia, Pavia, Italy

    V. Cosi

  • University Medical Center, Geneva, Switzerland

    Ann C. Kato

  • ALS/MND Research Foundation, Zurich, Switzerland

    W. Parlette

  • University of Milan, Milan, Italy

    P. Pinelli, M. Poloni

Bibliographic Information

  • Book Title: Amyotrophic Lateral Sclerosis

  • Book Subtitle: Therapeutic, Psychological, and Research Aspects

  • Editors: V. Cosi, Ann C. Kato, W. Parlette, P. Pinelli, M. Poloni

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-1-4684-5302-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature 1987

  • Softcover ISBN: 978-1-4684-5304-1Published: 26 November 2012

  • eBook ISBN: 978-1-4684-5302-7Published: 09 March 2013

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 357

  • Topics: Neurology, Psychotherapy and Counseling

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