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Toxic Substances and Human Risk

Principles of Data Interpretation

  • Book
  • © 1987

Overview

Editors:
  1. Robert G. Tardiff

    1. Environ Corporation, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Joseph V. Rodricks

    1. Environ Corporation, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Life Science Monographs (LSMO)

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xiii
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  2. Historical Perspectives and General Concepts

    1. Front Matter

      Pages 1-1
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    2. Introduction

      • John Doull
      Pages 3-12

    3. Toxicologic Units

      • Jeannee K. Yermakoff
      Pages 13-27

    4. Dose—Response Relationships

      • Rolf Hartung
      Pages 29-46

    5. Factors Modifying Toxicity

      • Gary P. Carlson
      Pages 47-76

    6. Statistical Interpretation of Toxicity Data

      • David W. Gaylor
      Pages 77-91

  3. Interpretation of Information from Human Studies

    1. Front Matter

      Pages 93-93
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    2. Clinical and Epidemiological Studies

      • James E. Cone, Gordon R. Reeve, Philip J. Landrigan
      Pages 95-120

    3. Comprehensive Evaluation of Human Data

      • David G. Hoel, Philip J. Landrigan
      Pages 121-130

  4. Interpretation of in Vivo Experimental Data for Evaluation of Hazards to Humans

    1. Front Matter

      Pages 131-131
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    2. Selection of Animal Models for Data Interpretation

      • Robert E. Menzer
      Pages 133-152

    3. Toxicokinetics

      • Edward R. Garrett
      Pages 153-235

    4. Approaches to Intraspecies Dose Extrapolation

      • Charles C. Brown
      Pages 237-268

    5. Extrapolation from Animal Data

      • Edward J. Calabrese
      Pages 269-280

    6. Approaches to Route Extrapolation

      • James R. Withey
      Pages 281-299

    7. Application of in Vivo Data on Chemical—Biological Interactions

      • Larry S. Andrews, Stephen L. Longacre, Robert Snyder
      Pages 301-316

    8. Computer-Assisted Prediction of Toxicity

      • Kurt Enslein
      Pages 317-336

  5. Interpretation of in Vitro Experimental Data for Evaluation of Hazards to Humans

    1. Front Matter

      Pages 337-337
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    2. Assessment of the Hazard of Genetic Toxicity

      • Ronald W. Hart, David Brusick
      Pages 339-355
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Keywords

About this book

As society has become increasingly aware of the potential threats to human health due to exposures to toxic chemicals in the environment and the workplace and in consumer products, it has placed increased demands upon the still-fledgling science of toxicology. As is often the case when science is called upon to supply firm answers when pertinent information and fundamental knowledge are lack­ ing, both the scientific and the social issues become confused and new tensions develop. One of the major purposes of this book is to focus on those aspects of the science of toxicology that pertain most to social issues-namely, analysis of risk for purposes of human health protection. Although it is apparent that the discipline of toxicology is not yet prepared to provide firm answers to many questions concerning human risk, it is important that the rigorously derived information be used in the most objective and logical way to yield the closest approximation to the truth. This book is designed to sup­ ply as much guidance for such tasks as is permitted by the current state of our knowledge. Its emphasis is thus placed on interpretation of toxicity data (broadly defined) for assessing risks to human health. In this way, it differs from other basic toxicology texts, most of which emphasize methods for performing studies or describe various toxicological endpoints and classes of toxic agents.

Editors and Affiliations

  • Environ Corporation, USA

    Robert G. Tardiff, Joseph V. Rodricks

Bibliographic Information

  • Book Title: Toxic Substances and Human Risk

  • Book Subtitle: Principles of Data Interpretation

  • Editors: Robert G. Tardiff, Joseph V. Rodricks

  • Series Title: Life Science Monographs

  • DOI: https://doi.org/10.1007/978-1-4684-5290-7

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Plenum Press, New York 1987

  • Softcover ISBN: 978-1-4684-5292-1Published: 07 May 2012

  • eBook ISBN: 978-1-4684-5290-7Published: 13 March 2013

  • Edition Number: 1

  • Number of Pages: XIII, 445

  • Topics: Waste Management/Waste Technology, Ecotoxicology

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