Nato Science Series A:

Radiation Carcinogenesis and DNA Alterations

Editors: Burns, Frederic J. (Ed.)

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About this book

This volume is based on the proceedings of an Advanced Study Institute (ASI) sponsored by the North Atlantic Treaty Organization (NATO) held October 1984 in Corfu, Greece. The meeting received finan­ cial support from the United States Department of Energy and the United States National Cancer Institute. A plethora of recent developments in the molecular biology of DNA are leading to new ideas concerning how DNA alterations might be involved in the mechanism of radiation carcinogenesis. Evidence is accumulating that genetic sequences, known as oncogenes, are involved in the translation of DNA molecular alterations into phenotypic changes associated with malignant cells. For example, a chromosome break often occurs at or near the loca­ tion of a specific oncogene in Burkitt's lymphoma. Such breaks could represent initial lesions in a translocation process that activates the oncogene by inserting it at a new location, eg., near an active pro­ moter. Since breakage of the DNA is one of the principal ways that ion­ izing radiation affects mammalian cells, these new molecular ideas sug­ gest ways that radiation-induced DNA breaks might be involved as initial events in carcinogenesis. While the possible involvement of oncogenes in radiation carcino­ genesis is an exciting new development, a direct sequential connection between early molecular changes in DNA and later tumor development has yet to be established. Accordingly, there is a tremendous need for experimental studies of how DNA alterations might convert normal cells to cancer cells.

Table of contents (49 chapters)

  • Follow-up Studies of Patients Treated by X-Ray Epilation for Tinea Capitis

    Albert, R. E. (et al.)

    Pages 1-25

  • Tumour Induction in Experimental Animals after Neutron and X-Irradiation

    Broerse, J. J.

    Pages 27-50

  • Dose-Response for Radiation-Induced Cancer in Rat Skin

    Burns, F. J. (et al.)

    Pages 51-70

  • Experimental Radiation Carcinogenesis

    Silini, G.

    Pages 71-105

  • Radiation Carcinogenesis and the Hair Follicle

    Sinclair, I. P. (et al.)

    Pages 107-114

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5269-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-5271-6
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Radiation Carcinogenesis and DNA Alterations
Editors
  • Frederic J. Burns
Series Title
Nato Science Series A:
Series Volume
124
Copyright
1986
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5269-3
DOI
10.1007/978-1-4684-5269-3
Softcover ISBN
978-1-4684-5271-6
Edition Number
1
Number of Pages
XI, 618
Number of Illustrations and Tables
110 b/w illustrations
Topics