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Advances in Experimental Medicine and Biology

Neurobiology of Central D1-Dopamine Receptors

Editors: Breese, George (Ed.)

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About this book

Our understanding of the functional mechanisms relating dopamine activity to normal and abnormal behavior has been turned "upside-down" by the recent developments described in the chapters of this volume. Heretofore, it was generally agreed that all of the pharmacological and behavioral properties ascribed to dopamine systems were mediated via activation or inhibition of the subtype of dopamine receptors termed D2. The properties of these receptors were first characterized in 1975 following their identification by receptor binding techniques utilizing 3H-butyrophenones, potent antipsychotic drugs, used in the treatment of schizophrenia. Although another subtype of dopamine receptor had already been identified a few years earlier, now termed the Dl receptor, its functional properties were unknow- other than the fact that it was associated with the activation of the enzyme adenylate cyclase. Our absence of knowledge of the behavioral functions of this receptor stemmed primarily from the lack of selective agonist and antagonists for DI receptors - drugs which did not also interact with D2 receptors. Selective agents for D2 receptors did exist and hence the behavioral roles of D2 receptors were easily ascribed. The work described in this text is primarily stimulated by the development of two selective Dl receptor drugs - the antagonist SCH 23390 and the agonist SKF 38393. The studies described herein clearly show that D1 receptors do indeed have many behavioral functions, on the surface often similar to those responses mediated by D2 receptors.

Table of contents (13 chapters)

Table of contents (13 chapters)
  • Benzazepines: Structure-Activity Relationships Between D1 Receptor Blockade and Selected Pharmacological Effects

    Pages 1-14

    Iorio, Louis C. (et al.)

  • Characterization of Dopamine D-1 and D-2 Receptors

    Pages 15-28

    Hyttel, John (et al.)

  • Biochemical and Behavioral Studies of D1 Dopamine Receptors Utilizing SCH 23390

    Pages 29-52

    Hess, Ellen J. (et al.)

  • The Multiplicity of the D1 Dopamine Receptor

    Pages 53-72

    Mailman, Richard B. (et al.)

  • The Dopamine D1 Receptor: Biochemical and Behavioral Aspects

    Pages 73-91

    Andersen, Peter H. (et al.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-5191-7
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-5193-1
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Neurobiology of Central D1-Dopamine Receptors
Editors
  • George Breese
Series Title
Advances in Experimental Medicine and Biology
Series Volume
204
Copyright
1986
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-5191-7
DOI
10.1007/978-1-4684-5191-7
Softcover ISBN
978-1-4684-5193-1
Series ISSN
0065-2598
Edition Number
1
Number of Pages
VIII, 219
Number of Illustrations
33 b/w illustrations, 1 illustrations in colour
Topics