Immunological Approaches to Contraception and Promotion of Fertility

1. Front Matter

   Pages i-x

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2. Inaugural Remarks

   • Craig K. Wallace

   Pages 1-2

3. Inaugural Remarks

   • Duane Alexander

   Pages 3-4

4. Whence the Anti Hormones?

   • Roy Hertz

   Pages 5-15

5. Immunological Approaches to Contraception: The Need, Basic Premise, and Overview

   • G. P. Talwar

   Pages 17-24

6. Lack of Toxicological Effects Following Seven Years of Active Immunization of Rhesus Monkeys with the β-Subunit of Ovine Luteinizing Hormone

   • R. B. Thau, M. G. Bond, S. S. Witkin, K. Sundaram, Janet K. Sawyer

   Pages 25-33

7. Reaction of a Chimpanzee to Immunization with oLHβ

   • N. R. Moudgal

   Pages 35-36

8. Improved Immunogenic Formulations for Antigonadotropin Response

   • N. C. Sharma, Om Singh, Amitabh Gaur, D. N. Rao, Vinod Singh, L. V. Rao et al.

   Pages 37-41

9. A Fertility Regulating Vaccine Based on the Carboxyl-Terminal Peptide of the Beta Subunit of Human Chorionic Gonadotrophin

   • P. D. Griffin

   Pages 43-59

10. Enhancement of Antibody Response to an Antigonadotropin Vaccine by use of Adjuvants

    • H. A. Nash, C. C. Chang, Y. Y. Tsong

    Pages 61-70

11. Rational Vaccine Design: Opportunities Offered by Molecular Genetics

    • N. A. Mitchison

    Pages 71-75

12. Cloning and Expression of Biologically Active Human Fertility Hormones

    • Vemuri B. Reddy, Anton K. Beck, Vincent Vellucci, Anthony J. Garramone, Edward G. Bernstine

    Pages 77-91

13. Cloning and Expression of Lutropin Genes

    • William W. Chin, Soheyla D. Gharib

    Pages 93-102

14. Development of oFSH as a Vaccine for the Male — A Status Report on the Recent Reasearches Carried Out Using the Bonnet Monkey (M. Radiata)

    • N. R. Moudgal, G. S. Murthy, A. J. Rao, N. Ravindranath, M. R. Sairam, S. G. Kotagi et al.

    Pages 103-110

15. Immunization Against FSH as a Method of Male Contraception

    • Jeffrey Spieler

    Pages 111-113

16. Effects of Active Immunization with Follicle Stimulating Hormone (FSH) on Spermatogenesis in the Adult Crab Eating Monkey- Evaluation for Male Contraception

    • H. G. Madhwa Raj

    Pages 115-123

17. LHRH Immunoneutralization: Basic Studies and Prospects for Practical Application

    • Hamish M. Fraser

    Pages 125-141

18. Immunization Against LHRH Without the Use of Freund’s Complete Adjuvant

    • C. Shaha, S. Kaul, M. Kini, M. Chowdhury, R. Anand, C. Das et al.

    Pages 143-150

19. Sperm Antigens, Immunologic Infertility and Contraception

    • A. C. Menge

    Pages 151-154

20. Transformation of the Nucleus During Mammalian Spermatogenesis and Fertilization: Implications for Contraceptive Development

    • Anthony R. Bellvé, Stuart B. Moss, Michael J. Donovan, Marion C. Usselman

    Pages 155-174

Contraceptive research has entered the new age of vaccines. Realistic prospects exist for the development of an entirely new battery of vaccines for use in human and veterinary medicine. Among them may be anti-fertility vaccines, based on physiological mechanisms applicable to either the female or male. This volume is a comprehensive review - a status report - of the subjects including fundamental work on the search for useful epitopes and ranging to applied vaccinology. One vaccine to prevent pregnancy, for use by women, has already been studied extensively. G.P. Talwar, the volume's editor and his colleagues in New Oelhi, India, published in 1976 a landmark series of papers describing the immunological properties of a preparation consisting of the alum-precipitated beta-subunit of human chorionic gonadotropin (hCG) chemically linked to tetanus toxoid. The principle of enhancing antigenicity of a self-protein by linkage of the epitope to a carrier protein was employed and tested clinically. These trials, carried out under the auspices of the Indian Council for Medical Research, were the first application of the carrier protein concept for a vaccine for human use. The encouraging results stimulated a wave of research not only on the use of hCG-based vaccines, but on other antigens as well.

• Embryo
• cloning
• development
• fertility
• medicine
• paper
• protein
• vaccine
• wave
• Tree Biology

• National Institute of Immunology, New Delhi, India

  G. P. Talwar

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