Advances in Experimental Medicine and Biology

Gene Expression in Muscle

Editors: Wolf, Stewart G. (Ed.)

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About this book

This volume contains the edited transcript of an interdisci­ plinary colloquium held at Totts Gap Medical Research Laboratories, Bangor, Pennsylvania on October 12-14, 1983 under the sponsorship of the Muscular Dystrophy Association. The aim was to illuminate the pathogenic mechanism of Duchenne Muscular Dystrophy through a synthesis of available data on gene expression in muscle. In the informal give and take ot the collo­ quium, the participants found themselves engaged in mutual education and enlightenment as they attempted to put together what is known and to highlight what is not known about the subject. Significant research into muscle as a tissue and muscle disease began only about 50 years ago although the description of muscular dystrophy by Guillaume Benjamin Amand Duchenne de Boulogne had been published in 1862. By 1943 it was clear that Duchenne muscular dystrophy was an X-linked genetic disorder. Up to the present, however, the offending gene has not been identified although its location on the short arm of the X chromosome has been approximately determined. The gene product associated with the initial disturbance in skeletal muscle has also remained elusive up to now. Moreover, investigations into the mechanisms of the muscle degeneration have been hampered by ignorance of the fundamental phenotypic expression of the genetic disorder.

Table of contents (32 chapters)

Table of contents (32 chapters)
  • Clinical Perspective: Phenotypic Expression in Muscular Dystrophy

    Pages 3-14

    Rowland, Lewis P.

  • Ontologic Perspective: Terminal Differentiation and Maturation as Differently Regulated Stages in Muscle Development

    Pages 15-22

    Strohman, Richard C. (et al.)

  • Hereditary Metabolic Myopathies

    Pages 25-42

    Miranda, Armand F. (et al.)

  • Myosin Isoforms in Normal and Dystrophic Human and Murine Muscles

    Pages 43-62

    Hoh, Joseph F. Y. (et al.)

  • Distribution of Slow Myosin in Dystrophic Chicken Muscle

    Pages 63-72

    Bandman, Everett

Buy this book

eBook $99.00
price for USA in USD
  • ISBN 978-1-4684-4907-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA in USD
  • ISBN 978-1-4684-4909-9
  • Free shipping for individuals worldwide
  • Institutional customers should get in touch with their account manager
  • Covid-19 shipping restrictions
  • Usually ready to be dispatched within 3 to 5 business days, if in stock
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Bibliographic Information

Bibliographic Information
Book Title
Gene Expression in Muscle
Editors
  • Stewart G. Wolf
Series Title
Advances in Experimental Medicine and Biology
Series Volume
182
Copyright
1985
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-4907-5
DOI
10.1007/978-1-4684-4907-5
Softcover ISBN
978-1-4684-4909-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 434
Topics