Genetic and Phenotypic Markers of Tumors

1. Front Matter

   Pages i-xi

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2. Introduction

   1. Phenotypic and Genetic Markers of Cancer: Turning Point in Research

      • Luigi Frati, Enrico Cortesi, Corrado Ficorella, Vittorio Manzari, Roberto Verna

      Pages 1-20

3. Phenotypic Markers

   1. Biochemical Markers

      1. Multiple Biochemical Markers for Cancer: A Statistical Approach

         • Paolo Marchetti, Enrico Cortesi, Corrado Ficorella, Luigi Frati

         Pages 21-25

      2. Pseudouridine: A Biochemical Marker for Cancer

         • Filiberto Cimino, Tommaso Russo, Alfredo Colonna, Francesco Salvatore

         Pages 27-39

      3. Serum Lipid Associated Sialic Acid in Different Human Malignances: Preliminary Results

         • L. Santamaria, N. Katopodis, G. Santagati, A. Bianchi, R. Pizzala, C. C. Stock

         Pages 41-47

      4. Heterogeneity of Binding Sites for Triphenylethylene Antiestrogens in Estrogen Target Tissues

         • Alberto Gulino, Jorge Raul Pasqualini

         Pages 49-65

      5. Failure to Demonstrate Plasma Hormone Abnormalities in Women with Operable Breast Cancer

         • I. Ricciardi, S. De Placido, C. Pagliarulo, G. Delrio, F. Citarella, L. De Sio et al.

         Pages 67-74

      6. Cell-Type-Independent Accumulation of Phosphatidic Acid Induced by Trifluoperazine in Stimulated Human Platelets, Leukocytes, and Fibroblasts

         • Marco Ruggiero, Gabriella Fibbi, Mario Del Rosso, Simonetta Vannucchi, Franca Pasquali, Vincenzo Chiarugi

         Pages 75-79

      7. Protease Inhibitors in 3T3 Cells

         • Gabriella Fibbi, Vincenzo Chiarugi, Mario Del Rosso

         Pages 81-84

      8. Heterogeneity of Extramitochondrial Forms of Aspartate Aminotransferase and Malate Dehydrogenase in Yoshida Ascites Hepatoma Cells

         • Pier Paolo Gazzaniga

         Pages 85-90

   2. Detection of Antigenic Markers by Monoclonal Antibodies

      1. Biology and Immunology of Human Carcinoma Cell Populations

         • J. Schlom, D. Colcher, P. Hand, D. Wunderlich, M. Nuti, R. Mariani-Costantini et al.

         Pages 91-105

      2. Monoclonal Antibodies Against Breast Cancer

         • M. I. Colnaghi, S. Mènard, R. Mariani-Costantini, S. Canevari, S. Miotti, G. Della Torre et al.

         Pages 107-115

      3. Generation of Monoclonal Antibodies Reactive with Human Colon Carcinomas

         • Raffaella Muraro, David Wunderlich, Jeffrey Schlom

         Pages 117-127

   3. Cellular Recognition of Phenotypic Markers

      1. Reactivity of Cultured Mouse Natural Killer (NK) Cells Against Normal Non-Neoplastic Cells

         • C. Riccardi, G. Migliorati, L. Frati, F. Guadagni, E. Bonmassar, R. B. Herberman

         Pages 129-137

      2. Modulating Effects of Thymic Factors on Natural Cell-Mediated Reactivities of Natural and Cyclophosphamide-Treated Mice

         • Francesco Bistoni, Manuela Baccarini, Lucia Scaringi, Rosanna Mazzolla, Paolo Puccetti, Pierfrancesco Marconi

         Pages 139-144

      3. Effect of Inactivated <u>C. Albicans</u> on Natural Killer (NK) Cell Activity and Blastogenesis in Mice

         • Pierfrancesco Marconi, Lucia Scaringi, Antonio Cassone, Luciana Tissi

         Pages 145-151

      4. Antitumor Adjuvants from Candida Albicans : Effects on Human Allogenic T-Cell Responses “In Vitro”

         • Clara Ausiello, Giulio Spagnoli, Francesca Mondello, Pierfrancesco Marconi, Francesco Bistoni, Antonio Cassone

         Pages 153-157

      5. IL-2 and Lymphocytes from Tumor Bearing Mice: A Combinatory Immunotherapy of Tumors

         • Guido Forni, Mirella Giovarelli, Susanna Cerruti Sola, Angela Santoni

         Pages 159-173

      6. Hyporesponsiveness of Natural Killer Activity Induced in Vivo By Multiple Treatment with Maleic Acid Anhydride Divinyl Ether (MVE-2)

         • Mario Piccoli, Angela Santoni, Francesca Velotti, M. Cristina Galli, Luigi Frati, Michael A. Chirigos

         Pages 175-187

      7. Epstein-Barr Virus Markers in Nasopharyngeal Carcinoma

         • Alberto Faggioni, Giuseppe Barile, Mario Piccoli, Luigi Frati

         Pages 189-197

The study of tumor markers is not only one of the most important but also one that offers one of the richest perspectives in biology and clinical oncology. The aim of scientists in this field is to adduce evidence of a property that is typical of and exclusive to tumor cells, and which is easy to determine, in order to immediately recognize, or even better, to foresee, neoplastic transformations. Unfortunately, despite the large number of scientists and laboratories engaged in this work, the ideal tumor marker has not yet been identified. However, it is worth noting that new trends in molecular biology and immunovirology have recently opened up new avenues that may lead to the eventual resolution of this problem. In this book, different approaches to the identification of tumor markers, from the points of view of biochemistry, immunology, and molecular biology, are compared in order to explore possible interrelationships and to stimulate scientific collaboration among scientists active in these fields, both in basic research and in clinical applications. We wish to thank all the contributors and also the publisher, especially Dr. Robert Andrews, for making the publication of this book possible.

• antibody
• antigen
• biology
• cells
• immunology
• immunotherapy
• interferon
• leukemia
• lymphocytes
• molecular biology
• oncology
• research
• tumor
• virology
• virus

• National Cancer Institute, National Institutes of Health, Bethesda, USA

  Stuart A. Aaronson

• Institute of General Pathology, Rome, Italy

  Luigi Frati, Roberto Verna

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