Advances in Experimental Medicine and Biology

Human Trophoblast Neoplasms

Editors: Pattillo, Ronald A. (Ed.)

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About this book

This book addresses neoplasms of the human trophoblast. The scant literature available on the epidemiology of trophoblast neoplasms suggests that they are as much as ten times more common in Africa, Asia, India, and much of the developing world than in Western countries. The stimulus for the book evolved out of a common interest to combine Western technology with the clinical experience in the developing world in a common pursuit of the study and eradication of trophoblast neoplasia. There is substantial evidence to contend that gene derepression as seen in trophoblastic disease may be a universal prerequisite to neoplastic transformation in general. The recent discovery that the tumor markers, human chorionic gonadotropin (hCG) or its subunits, are identifiable in over 90 percent of all extracted neoplasms suggests a critical role for this common denominator of gene derepression in neoplasia. This gene derepression concept in reproductive biology and neoplasia spans many of the basic parameters of human cell replication as related to endocrinology, immunology, biochemistry, electrophysiol­ ogy, genetics, and pharmacology. The International Society for the Study of Trophoblastic Disease focuses on the global aspects of trophoblast neoplasms. These global aspects include epidemiology and etiology of the disease, regional variations in treatment of trophoblastic neoplasms, and potential ways to adapt and apply Western technology to effective use in developing countries. It was this perspective that formed the basis for the First World Congress on Trophoblast Neoplasms, which convened in Nairobi in October, 1982.

Table of contents (28 chapters)

  • On the Nature of Gestational Trophoblastic Disease

    Hertz, Roy

    Pages 3-12

  • Exposure to Chemical Carcinogens During Pregnancy: Consequences for Mother and Conceptus

    Rice, Jerry M.

    Pages 13-49

  • Genetic Origin, Immunobiology, and Gonadotropin Expression in Trophoblast and Nontrophoblast Neoplasms

    Pattillo, Roland A.

    Pages 53-79

  • Immunology in Genesis of Partial and Total Hydatidiform Mole

    Takeuchi, Shoshichi

    Pages 81-110

  • Complement System in Abnormal Pregnancy and Chorionic Neoplasia: Immunotherapy and Chemotherapy of Chorionic Neoplasia

    Ohkawa, Ryoki (et al.)

    Pages 111-125

Buy this book

eBook $99.00
price for USA in USD (gross)
  • ISBN 978-1-4684-4811-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $129.00
price for USA in USD
  • ISBN 978-1-4684-4813-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Human Trophoblast Neoplasms
Editors
  • Ronald A. Pattillo
Series Title
Advances in Experimental Medicine and Biology
Series Volume
157
Copyright
1984
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-4811-5
DOI
10.1007/978-1-4684-4811-5
Softcover ISBN
978-1-4684-4813-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
X, 505
Topics