Nutritional and Toxicological Aspects of Food Safety

1. Front Matter

   Pages i-xii

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2. Naturally Occurring Phenolics as Antimutagenic and Anticarcinogenic Agents

   • Hans F. Stich, Miriam P. Rosin

   Pages 1-29

3. Sulfhydryl Groups and Food Safety

   • Mendel Friedman

   Pages 31-63

4. Interactions of Diet and Immunity

   • David L. Brandon

   Pages 65-90

5. Role of Epigenetic Factors in Dietary Carcinogenesis

   • David L. Berry, C. Tucker Helmes

   Pages 91-113

6. Defenses Against Aflatoxin Carcinogenesis in Humans

   • M. Sid Masri

   Pages 115-146

7. Metabolism of Food Toxicants: Saccharin and Aflatoxin B1, A Contrast in Metabolism and Toxicity

   • J. L. Byard

   Pages 147-151

8. Effect of Diet on T-2 Toxicosis

   • T. K. Smith, M. S. Carson

   Pages 153-167

9. Safety of Megavitamin Therapy

   • Stanley T. Omaye

   Pages 169-203

10. Prenatal and Developmental Toxicology of Arsenicals

    • Calvin C. Willhite, Vergil H. Ferm

    Pages 205-228

11. Differential Effects of Sodium Selenite and Methylmercury(II) on Membrane Permeability and DNA Replication in HeLa S3 Carcinoma Cells: A Preliminary Report Regarding the Modification of Organomercurial Toxicity by Selenium Compounds

    • D. W. Gruenwedel

    Pages 229-240

12. Structure and Stereochemistry of Steroidal Amine Teratogens

    • William Gaffield, Richard F. Keeler

    Pages 241-251

13. Minimizing the Saponin Content of Alfalfa Sprouts and Leaf Protein Concentrates

    • A. L. Livingston, B. E. Knuckles, L. R. Teuber, O. B. Hesterman, L. S. Tsai

    Pages 253-268

14. The Influence of 1-(N-L-Tryptophan)-1-Deoxy-D-Fructose [FRU-TRP] and its N-Nitrosated Analogue [NO-FRU-TRP] on the Viability and Intracellular Synthetic Activity (DNA, RNA, and Protein Synthesis) of HeLa S3-Carcinoma Cells

    • D. W. Gruenwedel, S. C. Lynch, G. F. Russell

    Pages 269-285

15. Sources of N-Nitrosamine Contamination in Foods

    • Joseph H. Hotchkiss

    Pages 287-298

16. Nutritional and Metabolic Response to Plant Inhibitors of Digestive Enzymes

    • Daniel Gallaher, Barbara O. Schneeman

    Pages 299-320

17. Nutritional Studies of a Carboxypeptidase Inhibitor from Potato Tubers

    • Gregory Pearce, James McGinnis, Clarence A. Ryan

    Pages 321-332

18. Stability of Enzyme Inhibitors and Lectins in Foods and the Influence of Specific Binding Interactions

    • James C. Zahnley

    Pages 333-365

19. Protein-Alkali Reactions: Chemistry, Toxicology, and Nutritional Consequences

    • Mendel Friedman, Michael R. Gumbmann, Patricia M. Masters

    Pages 367-412

20. Effect of Protein Treatment on the Enzymatic Hydrolysis of Lysinoalanine and other Amino Acids

    • Laurent Savoie

    Pages 413-422

Naturally occurring antinutrients and food toxicants, and those formed during food processing, adversely affect the nutri­ tional quality and safety of foods. Because of the need to improve food quality and safety by plant breeding, fortification with appropriate nutrients, and processing methods, and because of the growing concern about possible direct relationships between diet and diseases, research is needed to: (1) evaluate the nutritive quality and safety of crops and fortified, supplemented, and processed foods; (2) define conditions that favor or minimize the formation of nutritionally antagonistic and toxic compounds in foods; and (3) define the toxicology, metabolism, and mechanisms of the action of food ingredients and their metabolites. As scientists interested in improving the safety of the food supply, we are challenged to respond to the general need for exploring: (1) possible adverse consequences of antinutrients and food toxicants; and (2) factors which contribute to the formation and inactivation of undesirable compounds in foods. Medical research offers an excellent analogy. Studies on causes and mechanisms of disease processes are nearly always accompanied by parallel studies on preventive measures and cures. Such an approach offers the greatest possible benefits to the public.

• chemistry
• enzyme
• membrane
• metabolism
• nutrition
• plant
• protein
• toxicology

• Agricultural Research Service Western Regional Research Center, U.S. Department of Agriculture, Berkeley, USA

  Mendel Friedman

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