Advances in Experimental Medicine and Biology

Contractile Mechanisms in Muscle

Editors: Pollack, Gerald (Ed.)

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About this book

Prior to the emergence of the sliding filament model, contraction theories had been in abundance. In the absence of the kinds of structural and biochemical information available today, it has been a simple matter to speculate about the possible ways in which tension generation and shortening might occur. The advent of the sliding filament model had an immediate impact on these theories; within several years they fell by the wayside, and attention was redirected towards mechanisms by which the filaments might be driven to slide by one another. In terms of identifying the driving mechanism, the pivotal observa­ tion was the electron micrographic indentification of cross-bridges extending from the thick filaments. It was quite naturally assumed that such bridges, which had the ability to split ATP, were the molecular motors, i.e., that they were the sites of mechanochemical transduction. Out of this presumption grew the cross-bridge model. in which filament sliding is presumed to be driven by the cyclic interaction of cross-bridges with complementary actin sites located along the thin filaments.

Table of contents (47 chapters)

Table of contents (47 chapters)

Buy this book

eBook $169.00
price for USA in USD (gross)
  • ISBN 978-1-4684-4703-3
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $219.99
price for USA in USD
  • ISBN 978-1-4684-4705-7
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Contractile Mechanisms in Muscle
Editors
  • Gerald Pollack
Series Title
Advances in Experimental Medicine and Biology
Series Volume
170
Copyright
1984
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-4703-3
DOI
10.1007/978-1-4684-4703-3
Softcover ISBN
978-1-4684-4705-7
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXXII, 921
Topics