Advances in Experimental Medicine and Biology

Purine Metabolism in Man-IV

Part A: Clinical and Therapeutic Aspects; Regulatory Mechanisms

Editors: De Bruyn, Chris H. (Ed.)

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About this book

These two volumes, entitled "Purine Metabolism in Man IV" con­ tain the paper presented at the "IV. International Symposium on Human Purine and Pyrimidine Metabolism," held in Maastricht (The Netherlands), June 1982. The proceedings of the three previous meet­ ings in Tel Aviv (Israel, 1973), Baden (Austria, 1976) and Madrid (Spain, 1979) were also published by Plenum Press. In the past few years interest in purine and pyrimidine metabo­ lism under normal and pathological conditions has been growing rapid­ ly. Apart from the more or less classical topics such as hyperuricae­ mia, clinical gout and urolithiasis, an increasing number of papers relating to other fields have been presented at successive meetings. Knowledge derived from the study of purine metabolism in relation to lymphocyte function, for instance, has opened up new possibilities for immunomodulation and leukaemia chemotherapy, with eventual conse­ quences for other types of cancer. At previous meetings there have been pointers implicating purine metabolism in relation to normal cardiac and skeletal muscle function. During the present meeting much new data on both issues have been re­ ported which indicate clear differences in the pathways of ATP metabo­ lism. The widening of the field of interest is also illustrated by the recent work on infectious disease: exploitation of the differences in purine metabolic pathways in certain parasites compared with those in human cells has resulted in new rationales for therapy being devel­ oped.

Table of contents (49 chapters)

  • Problems in Diagnosis and Treatment of Adenine and Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency

    Dillon, M. J. (et al.)

    Pages 1-6

  • Problems of Diagnosis in an Adolescent with Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency and Acute Renal Failure

    Cameron, J. S. (et al.)

    Pages 7-12

  • Hypoxanthine-Guanine Phosphoribosyl Transferase (HGPRT) Deficiency in a Girl

    Ogasawara, N. (et al.)

    Pages 13-18

  • Clinical and Biochemical Correlates of A New HPRT Mutation

    Gruber, H. E. (et al.)

    Pages 19-22

  • Enzyme Replacement in the Lesch-Nyhan Syndrome with Long-Term Erythrocyte Transfusions

    Edwards, N. Lawrence (et al.)

    Pages 23-26

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-4553-4
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-4555-8
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Purine Metabolism in Man-IV
Book Subtitle
Part A: Clinical and Therapeutic Aspects; Regulatory Mechanisms
Editors
  • Chris H. De Bruyn
Series Title
Advances in Experimental Medicine and Biology
Series Volume
165
Copyright
1984
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-4553-4
DOI
10.1007/978-1-4684-4553-4
Softcover ISBN
978-1-4684-4555-8
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XVII, 555
Topics