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Chemical Carcinogenesis

  • Book
  • © 1982

Overview

Editors:
  1. Claudio Nicolini

    1. Temple University Health Sciences Center, Philadelphia, USA
      National Research Council, Genoa, Italy

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Part of the book series: NATO Science Series A: (NSSA, volume 52)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-ix
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  3. DNA Adducts

    1. Front Matter

      Pages N3-N3
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    2. DNA Lesions : Nature and Genesis

      • P. A. Cerutti
      Pages 75-92

    3. DNA Alkaline Elution: Physical Basis of the Elution Process and Validation of this Method as a Screening Procedure to Identify Chemical Carcinogens

      • Claudio Nicolini, Marco Cavanna, Annalisa Maura, Albiana Pino, Luigi Robbiano, Felice Biassoni et al.
      Pages 93-119

    4. DNA Fragmentation: Its Predictivity as a Short Term Test

      • Silvio Parodi, Maurizio Taningher, Leonardo Santi
      Pages 121-154

    5. Measurement of Viscous and Elastic Components of Native DNA Fiber Following Carcinogen Administration

      • Claudio Nicolini, Giuseppe Accornero
      Pages 155-165

    6. Initiation of Experimental Liver Carcinogenesis by Chemicals: Are the Carcinogen Altered Hepatocytes Stimulated to Grow into Foci by Different Selection Procedures Identical?

      • A. Columbano, G. M. Ledda, P. M. Rao, S. Rajalakshmi, D. S. R. Sarma
      Pages 167-178

    7. Influence of DNA Conformation on DNA Methylation and the Direct Binding of N-Methyl-N-Nitroso-N1-Nitroguanidine

      • S. Rajalakshmi, M. Jamaludin, D. S. R. Sarma
      Pages 179-191

    8. Genotoxic Effects of Drugs: Experimental Findings Concerning Some Chemical Families of Therapeutic Relevance

      • G. Brambilla, M. Cavanna, S. De Flora
      Pages 193-221

  4. Chemicals as Promotors

    1. Front Matter

      Pages N5-N5
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    2. Phenobarbital and other Liver Tumor Promoters

      • R. Schulte-Hermann, J. Schuppler, G. Ohde, W. Bursch, I. Timmermann-Trosiener
      Pages 231-260

    3. Molecular Mechanisms of Multistage Carcinogenesis

      • I. Bernard Weinstein
      Pages 261-278

    4. Alterations of Liver Architecture in Mice Treated with Anabolic Androgens and Diethylnitrosamine

      • W. Taylor, S. Snowball, C. M. Dickson, Milena Lesna
      Pages 279-288

  5. Carcinogenesis as Multistep Process

    1. Front Matter

      Pages N7-N7
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    2. Some Critical Consideration Concerning Sequential Analysis of Carcinogenesis with Chemicals

      • Emmanuel Farber
      Pages 295-313
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Keywords

About this book

During October 18-30, 1981, the second course of the International School of Pure and Applied Biostructure, a NATO Advanced Study Institute, was held at the Ettore Majorana Center for Scientific Culture in Erice, Italy, co-sponsored by the International Union Against Cancer, the Italian League Against Cancer, the Italian Ministry of Public Education, the Italian Ministry of Scientific and Technological Research, the North Atlantic Treaty Organization, the Italian National Research Council, the Sicilian Regional Government and two pharmaceutical Companies (Zambeletti and Farmitalia). The subject of the course was "Chemical Carcino­ genesis" with participants selected world-wide from 18 different countries. It is now eminently clear that.the bulk of human cancers are related to one of several types of environmental exposure. Of the environmental hazards, chemicals are among the best characterized carcinogens. However, how chemicals induce cancer is still poorly understood. Because of the magnitude of the problem and the ob­ vious need for a much more critical scientific analysis of the process by which cancer is induced (carcinogenesis), it was highly desirable to expose a greater number of scientists with varying background to some of the latest thinking in chemical carcino­ genesis. The course had this as its major objective and the re­ sulting book does reflect it.

Editors and Affiliations

  • Temple University Health Sciences Center, Philadelphia, USA

    Claudio Nicolini

  • National Research Council, Genoa, Italy

    Claudio Nicolini

Bibliographic Information

  • Book Title: Chemical Carcinogenesis

  • Editors: Claudio Nicolini

  • Series Title: NATO Science Series A:

  • DOI: https://doi.org/10.1007/978-1-4684-4334-9

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1982

  • Softcover ISBN: 978-1-4684-4336-3Published: 25 November 2012

  • eBook ISBN: 978-1-4684-4334-9Published: 09 March 2013

  • Edition Number: 1

  • Number of Pages: XI, 492

  • Number of Illustrations: 36 b/w illustrations

  • Topics: Veterinary Medicine/Veterinary Science

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