Immunobiology of Proteins and Peptides—II

1. Front Matter

   Pages i-viii

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2. Molecular Aspects of T- and B-Cell Recognition of Protein Antigens

   1. Front Matter

      Pages 1-1

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   2. Autoimmunity to Myelin Basic Protein

      • Robert H. Swanborg, James H. Holda, Joyce A. Killen

      Pages 3-22

   3. The Use of Hybridoma Antibodies to Probe the Antigenic Determinants of Thyroglobulin

      • N. R. Rose, M. Accavitti, E. F. Pydyn, M. A. Leon, R. K. Brown

      Pages 23-35

   4. The Major B and T Cell Determinant on Pigeon Cytochrome c in B10.A Mice

      • Charles Hannum, Michiel Ultee, Louis A. Matis, Ronald H. Schwartz, E. Margoliash

      Pages 37-51

   5. Helper T Cells Specific for Protein Antigens: Role of Self Major Histocompatibility Complex and Immunoglobulin Gene Products

      • Charles A. Janeway Jr., Kim Bottomly, Barry Jones, Patricia P. Jones, Ethan A. Lerner, Louis A. Matis et al.

      Pages 53-71

   6. Dissection of the Molecular Parameters for T-Cell Recognition of a Myoglobin Antigenic Site

      • Colin R. Young, M. Zouhair Atassi

      Pages 73-93

3. Genetic Control of the Immune Response to Proteins and Peptides

   1. Front Matter

      Pages 95-95

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   2. Genetic Control and Intersite Influences on the Immune Response to Sperm Whale Myoglobin

      • Chella S. David, M. Zouhair Atassi

      Pages 97-125

   3. Genetic Control of the Immune Response to Hemoglobin and its Subunits

      • Christopher J. Krco, A. Latif Kazim, M. Zouhair Atassi, Chella S. David

      Pages 127-140

   4. Immune Response Gene Control of T Dependent Reactivity to Collagen in Man

      • Alan M. Solinger, John D. Stobo

      Pages 141-155

4. Regulation of the Immune Response

   1. Front Matter

      Pages 157-157

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   2. Myoglobin-Reactive T Cell Clones

      • A. J. Infante, M. Z. Atassi, C. G. Fathman

      Pages 159-167

   3. Use of T Cell Hybridomas in the Analysis of Helper T Cell Functions in B Cell Responses

      • Neal Roehm, John Kappler, Philippa Marrack

      Pages 169-182

   4. Regulation of Growth and Differentiation in B Cell Clones and Hybrids

      • David W. Scott, P. S. Pillai, Scott J. Anderson, Ronald B. Corley

      Pages 183-200

   5. Immunological Studies with Tobacco Mosaic Virus Protein: Differential Activation of B Cell Subpopulations

      • Donna M. Rennick, Philip R. Morrow, Eli Benjamini

      Pages 201-218

   6. Antigen Bridging in the Interaction of T Helper Cells and B Cells

      • Joel W. Goodman, Danute E. Nitecki, Sherman Fong, Zehra Kaymakcalan

      Pages 219-225

5. Back Matter

   Pages 227-230

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The immune response is largely dependent on molecular inter­ actions involving proteins. The recognition of antigen molecules, whether they are proteins or non-proteins, whether they are self or non-self, takes place at the molecular-cellular interface through membrane receptor molecules that are proteins. The initial step of recognition activates a complex series of cellular events requiring some mechanism of cell-cell interactions and communi­ cations, eventually leading to antibody production. This biolo­ gical cascade is controlled at several positions along its con­ secutive pathways by protein molecules, either in the free form or as receptors on membranes of cells committed to this activity. Clearly, then, the proper understanding of the response by cells of the immune system will depend, to a great measure, on the definition of the molecular events involving protein interactions. Obviously, cells work via molecules and molecules work via cells and, at this level of functional resolution, molecular immunology and cellular immunology will merge and will depend heavily on protein chemistry.

• antibody
• antigen
• immune response
• immune system
• immunobiology
• immunology
• proteins

• Mayo Clinic, Rochester, USA

  M. Z. Atassi

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