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Genetic Engineering of Microorganisms for Chemicals

  • Book
  • © 1982

Overview

Part of the book series: Basic Life Sciences (BLSC, volume 19)

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Table of contents (33 chapters)

Keywords

About this book

The normal course of most biologically catalyzed processes is tightly regulated at the genetic and physiological levels. The regulatory mechanisms are diverse, sometimes redundant, and it is becoming increasingly apparent that, at the genetic level, the range of mechanisms may be limited only by the permutations and combina­ tions available. For each microbial cell, evolution appears to have resulted in maximized advantage to that cell, achieving regulatory balance. Genetic engineering encompasses our attempts to perturb the genetic regulation of a cell so that we may obtain desired other than normal outcomes, such as increased product formation, or new product formation. Following the groundwork established by a preceding symposium (Trends in the Biology of Fermentations for Fuels and Chemicals, Brookhaven National Laboratory, December 1980), the initial planning for this conference envisioned the juxtaposition of molecular genetic expertise and microbial biochemical expertise. The resultant interaction should encourage new and extended ideas for the improve­ ment of strains and for the generation of new regulatory combina­ tions to enhance microbial chemical production from cheap and abundant (including waste) substrates. The interaction should also demonstrate that new discoveries at the basic level remain essential to progress in genetic engineering. New genetic regulatory combina­ tions require new studies of physiology and biochemistry to assure understanding and control of the system. New biochemical reactions necessitate new studies of genetic and regulatory interaction.

Editors and Affiliations

  • Associated Universities, Inc., USA

    Alexander Hollaender

  • Department of Microbiology, University of Illinois, Champaign, USA

    Ralph D. DeMoss

Bibliographic Information

  • Book Title: Genetic Engineering of Microorganisms for Chemicals

  • Editors: Alexander Hollaender, Ralph D. DeMoss, Samuel Kaplan, Jordan Konisky, Dwayne Savage, Ralph S. Wolfe

  • Series Title: Basic Life Sciences

  • DOI: https://doi.org/10.1007/978-1-4684-4142-0

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1982

  • Softcover ISBN: 978-1-4684-4144-4Published: 25 November 2012

  • eBook ISBN: 978-1-4684-4142-0Published: 09 April 2013

  • Edition Number: 1

  • Number of Pages: XIII, 486

  • Topics: Biomedical Engineering and Bioengineering

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