Skip to main content
SpringerLink
Log in
Book cover

In Situ Expression of Tumor Immunity

  • Book
  • © 1980

Overview

Editors:
  1. Isaac P. Witz

    1. Department of Microbiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. M. G. Hanna

    1. Cancer Biology Program, NCI Frederick Cancer Research Center, Frederick, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Contemporary topics in immunobiology (CTI, volume 10)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (15 chapters)

  1. Front Matter

    Pages i-xviii
    Download chapter PDF

  2. A Review of Data, Problems, and Open Questions Pertaining to in Situ Tumor Immunity

    • Stephen W. Russell, Isaac P. Witz, Ronald B. Herberman
    Pages 1-20

  3. Separation of Individual Kinds of Cells from Tumors

    • Thomas G. Pretlow II, Theresa P. Pretlow
    Pages 21-59

  4. Immunologic Reactivity of Lymphoid Cells in Tumors

    • Ronald B. Herberman, Howard T. Holden, Luigi Varesio, Tadayoshi Taniyama, Paolo Puccetti, Holger Kirchner et al.
    Pages 61-78

  5. Separation and Characteristics of Tumor-Infiltrating Lymphocytes in Man

    • E. Klein, F. Vánky, U. Galili, B. M. Vose, M. Fopp
    Pages 79-107

  6. Intratumor Host Cells of Experimental Rat Neoplasms: Characterization and Effector Function

    • M. Moore, K. Moore
    Pages 109-142

  7. Evidence for Mononuclear Phagocytes in Solid Neoplasms and Appraisal of Their Nonspecific Cytotoxic Capabilities

    • Stephen W. Russell, G. Yancey Gillespie, Judith L. Pace
    Pages 143-166

  8. Mononuclear Cells IgG Associated with Human Malignant Tissue

    • O. Tønder, R. Matre, F. Wesenberg
    Pages 167-176

  9. Evidence for Membrane-Bound Antibodies Directed against Antigens Expressed on Tumors

    • S. von Kleist, M. King, C. Huet
    Pages 177-189

  10. Tumor-Localizing Lymphocytotoxic Antibodies

    • Maya Ran, Margalit Yaakubowicz, Ora Amitai, Isaac P. Witz
    Pages 191-211

  11. Correlations between Tumor Antigenicity, Malignant Potential, and Local Host Immune Response

    • Harry L. Ioachim
    Pages 213-238

  12. Host Cell Analysis of a Rapidly Metastasizing Mouse Tumor and Derived Low-Metastatic Variant Lines

    • R. S. Kerbel, R. R. Twiddy, P. Frost
    Pages 239-253

  13. Cellular Basis for Regulation of Tumor Growth

    • Robert Evans
    Pages 255-266

  14. Immunological Stimulation in Situ: The Acute and Chronic Inflammatory Responses in the Induction of Tumor Immunity

    • M. G. Hanna Jr., C. D. Bucana, V. A. Pollack
    Pages 267-296

  15. Tumor Immunity in the Peritoneal Cavity

    • Gideon Berke, Barbara Schick
    Pages 297-315

  16. The Multicellular Tumor Spheroid: A Quantitative Model for Studies of in Situ Immunity

    • H. Robson MacDonald, Bernard Sordat
    Pages 317-342

  17. Back Matter

    Pages 343-348
    Download chapter PDF
Back to top

Keywords

About this book

Because of several valid (and some invalid) reasons, the research field of tumor immunology has been declining in popularity. The Simplistic dogmas, articles of faith, and theories of the late 1960s and early 1970s on the immuno­ logical mechanisms of the host-tumor interrelationships have frequently been refuted by some of the new developments in cancer biology, cancer biochem­ istry, and immunology. Furthermore, some of the conventional assays used to monitor "tumor-host immune relations" did not always reflect the host's true clinical situation or his prognosis. Several approaches to immunological interven­ tion were less successful than expected. In addition, the concept of "immune surveillance," which was basic to many researchers in the field of cancer im­ munology, seemed to fall apart. Much of the criticism was based on results from solid, well-performed, and well-controlled experiments, but there was also un­ just criticism based on ill-conceived and badly performed studies, and on misin­ terpretations of experimental data. There are many misconceptions about the tumor-host relationship. It is very often assumed that tumor immunity, as expressed systemically, is truly reflected at the tumor site. Several studies reported in this volume and elsewhere indicate that such is not always the case. Certain immune effectors may be selectively prevented from reaching the tumor site or the close vicinity of the tumor cells because of mechanical or chemical barriers, whereas others may be selectively attracted to the site by chemotaxis or other mechanisms.

Editors and Affiliations

  • Department of Microbiology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

    Isaac P. Witz

  • Cancer Biology Program, NCI Frederick Cancer Research Center, Frederick, USA

    M. G. Hanna

Bibliographic Information

  • Book Title: In Situ Expression of Tumor Immunity

  • Editors: Isaac P. Witz, M. G. Hanna

  • Series Title: Contemporary topics in immunobiology

  • DOI: https://doi.org/10.1007/978-1-4684-3677-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1980

  • Softcover ISBN: 978-1-4684-3679-2Published: 15 May 2013

  • eBook ISBN: 978-1-4684-3677-8Published: 11 November 2013

  • Edition Number: 1

  • Number of Pages: XVIII, 348

  • Topics: Immunology

Publish with us

Policies and ethics

Back to top

Search

Navigation