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Advances in Experimental Medicine and Biology

Modulators, Mediators, and Specifiers in Brain Function

Interactions of Neuropeptides, Cyclic Nucleotides, and Phosphoproteins in Mechanisms Underlying Neuronal Activity, Behavior, and Neuropsychiatric Disorders

Editors: Erlich, Y. H. (Ed.)

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About this book

While neuroanatomy and neurophysiology were defining the unique features of the synapse as a site for cell to cell signaling in the late fifties, neurochemistry was establishing the identity and studying the biosynthetic pathways of monoamine neurotransmitters. Meanwhile, neuropsychiatry was keeping a vigilant eye on the outcome of this concerted effort with the untold hope that a genetic defect in neurotransmitter metabolism would ac­ count for the pathogenesis of certain psychiatric ill­ nesses. Thus, when neurochemists in the early sixties began to study the feasibility of measuring the metabolism of brain neurotransmitters in vivo, clinical biochemists eagerly adopted these methods to their needs and sought to verify whether inborn errors of transmitter biogenesis were a cause for at least certain forms of depression, mania and schizophrenia. Undoubtedly, it is still too early to evaluate the outcome of these studies. However, current opinion holds that gross inborn errors in transmitter metabolism do not anpear to be operative as a primary cause of psychia­ tric disorders. Though monoamine metabolism appears to be defective in certain groups of psychiatric disorders, the cause of these changes can at best be associated with changes in patterns of neuronal firing. It is generally believed that these persistent changes are determined by a number of unknown factors operative in various psychia­ tric illnesses. In the attempt to identify the molecular nature of these unknown factors, the focus of current research is directed toward transmitter receptors.

Table of contents (18 chapters)

Table of contents (18 chapters)
  • Three Modes of Communication in the Nervous System

    Pages 3-25

    Barker, Jeffery L. (et al.)

  • Do Behaviorally Active Polypeptide Hormones Act at Crucial “Command” Sites or at Many Sites, from “Command” Down to “Final Common Paths”?

    Pages 27-39

    Ram, Jeffrey L.

  • Neurotransmitters and Neuromodulators and their Mediation by Cyclic Nucleotides

    Pages 41-64

    Siggins, G. R.

  • Metabolic Factors Affecting Brain Cyclic Nucleotides

    Pages 65-74

    Volicer, L. (et al.)

  • Phosphoproteins as Specifiers for Mediators and Modulators in Neuronal Function

    Pages 75-101

    Ehrlich, Yigal H.

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-3503-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-3505-4
  • Free shipping for individuals worldwide
  • Immediate ebook access, if available*, with your print order
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Modulators, Mediators, and Specifiers in Brain Function
Book Subtitle
Interactions of Neuropeptides, Cyclic Nucleotides, and Phosphoproteins in Mechanisms Underlying Neuronal Activity, Behavior, and Neuropsychiatric Disorders
Editors
  • Y. H. Erlich
Series Title
Advances in Experimental Medicine and Biology
Series Volume
116
Copyright
1979
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-3503-0
DOI
10.1007/978-1-4684-3503-0
Softcover ISBN
978-1-4684-3505-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XV, 327
Topics

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