Get your next eBook for only 9.99! Stock up on Springer Protocols! Available through Aug 17, 2018.

Advances in Experimental Medicine and Biology

Purine Metabolism in Man—II

Physiology, Pharmacology, and Clinical Aspects

Editors: Muller, Mathias M. (Ed.)

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-3285-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-3287-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
About this book

The study of gouty arthritis has provided a common meeting ground for the research interests of both the basic scientist and the clinician. The interest of the chemist in gout began 1776 with the isolation of uric acid from a concretion of the urinary tract by the Swedish chemist SCHEELE. The same substance was subsequently extracted from a gouty tophus by the British chemist WOLLASTONE in 1797 and a half century later the cause of the deposits of sodium urate In such tophi was traced to a hyperuricemia in the serum of gouty patients by the British physician Alfred Baring GARROD who had also received training in the chemical laboratory and was therefore a fore-runner of many of today's clinician-investigators. The recent surge of progress in understanding of some of the causes of gout in terms of specific enzyme defects marks the entrance of the biochemist into this field of investigation. The identification of the first primary defect of purine metabolism associated with over-production of uric acid, a severe or partial deficiency of the enzyme hypoxanthine-guanine phospho­ ribosyl transferase was achieved less than a decade ago. The knowledge of the mechanism of purine over-production that it generated led shortly to the identification of families carrying a dominantly (possibly X-linked) inherited increase in the activity of the enzyme phosphoribosylpyrophosphate synthetase as a cause of purine over-production. Yet this is only a start as these two types of enzyme defects account for less than five per cent of gouty patients.

Table of contents (49 chapters)

  • Renal Handling of Uric Acid

    Rieselbach, Richard E.

    Pages 1-22

  • The Effect of Urine Flow Rate on Urate Clearance

    Emmerson, B. T. (et al.)

    Pages 23-29

  • Effects of Vitamins on the Renal Handling of Uric Acid

    Fox, Irving H. (et al.)

    Pages 30-35

  • The Uricosuric Action of Amino Acids in Man

    Matzkies, F. (et al.)

    Pages 36-40

  • Urate Excretion in Normal and Gouty Men

    Simkin, Peter A.

    Pages 41-45

Buy this book

eBook $84.99
price for USA in USD (gross)
  • ISBN 978-1-4684-3285-5
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $109.00
price for USA in USD
  • ISBN 978-1-4684-3287-9
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
Loading...

Recommended for you

Loading...

Bibliographic Information

Bibliographic Information
Book Title
Purine Metabolism in Man—II
Book Subtitle
Physiology, Pharmacology, and Clinical Aspects
Editors
  • Mathias M. Muller
Series Title
Advances in Experimental Medicine and Biology
Series Volume
76B
Copyright
1977
Publisher
Springer US
Copyright Holder
Springer Science+Business Media New York
eBook ISBN
978-1-4684-3285-5
DOI
10.1007/978-1-4684-3285-5
Softcover ISBN
978-1-4684-3287-9
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXII, 373
Topics