Advances in Experimental Medicine and Biology

Hemoglobin and Red Cell Structure and Function

Proceedings of the Second International Conference on Red Cell Metabolism and Function held at the University of Michigan Ann Arbor, April 27–29, 1972

Editors: Brewer, George (Ed.)

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About this book

Hemoglobin and the red cell have continued to set a dizzying pace as the objects of research in the two and one-half year interval since the First International Conference on Red Cell Metabolism and Function. Most exciting perhaps, is a beginning molecular attack on sickle cell disease. The story of the inter­ action of red cell metabolism and oxygen transport has continued to unfold, and we can now infer that patients with hypoxia usually utilize red cell metabolic adjustments to improve oxygenation. This puts the red cell squarely in the center of medical practice, since much of medicine-heart, pulmonary, and blood disease- deals with inadequate oxygenation. On April 27th through the 29th, 1972, crystallographers, chemists, biochemists, physiologists, geneticists, and physi­ cians from many medical disciplines met in the Towsley Center for Continuing Medical Education at the University of Michigan, Ann Arbor to present new data, to review recent developments, and to try to piece together additional features of the red cell puzzle. The meeting was dedicated to Dr. Francis John Worsley Roughton, Professor Emeritus of Colloid Science, University of Cambridge, England, in recognition of his numerous excellent contributions to the understanding of hemoglobin and red cell function. The program got off to a good start with a paper from M. F. Perutz, Nobel Laureate, on the structure of hemoglobin. Dr.

Table of contents (38 chapters)

  • Structure of Haemoglobin M Milwaukee, A Mutant Form Exhibiting Interaction Between Ferrous and Ferric Subunits

    Perutz, M. F. (et al.)

    Pages 3-18

  • The Interaction Between Hemoglobin and Its “Oxygen-Linked” Ligands

    Brenna, O. (et al.)

    Pages 19-40

  • The Interaction of Sickle Hemoglobin with DPG, CO2 and with Other Hemoglobins: Formation of Asymmetrical Hybrids

    Bunn, H. Franklin

    Pages 41-53

  • Enhancement of the Acid and Alkaline Bohr Effects of Hemoglobin by Organic Phosphates

    Riggs, Austen (et al.)

    Pages 55-63

  • Functional Non-Equivalence of α and β Hemes in Human Hemoglobins

    Ho, Chien (et al.)

    Pages 65-76

Buy this book

eBook $119.00
price for USA in USD (gross)
  • ISBN 978-1-4684-3222-0
  • Digitally watermarked, DRM-free
  • Included format: PDF
  • ebooks can be used on all reading devices
  • Immediate eBook download after purchase
Softcover $159.99
price for USA in USD
  • ISBN 978-1-4684-3224-4
  • Free shipping for individuals worldwide
  • Usually dispatched within 3 to 5 business days.
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Bibliographic Information

Bibliographic Information
Book Title
Hemoglobin and Red Cell Structure and Function
Book Subtitle
Proceedings of the Second International Conference on Red Cell Metabolism and Function held at the University of Michigan Ann Arbor, April 27–29, 1972
Editors
  • George Brewer
Series Title
Advances in Experimental Medicine and Biology
Series Volume
28
Copyright
1972
Publisher
Springer US
Copyright Holder
Plenum Press, New York
eBook ISBN
978-1-4684-3222-0
DOI
10.1007/978-1-4684-3222-0
Softcover ISBN
978-1-4684-3224-4
Series ISSN
0065-2598
Edition Number
1
Number of Pages
XXXII, 526
Topics