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Brain Chemistry and Mental Disease

Proceedings of a Symposium on Brain Chemistry and Mental Disease held at the Texas Research Institute, Houston, Texas, November 18–20, 1970

  • Conference proceedings
  • © 1971

Overview

Editors:
  1. Beng T. Ho

    1. Texas Research Institute of Mental Sciences, Texas Medical Center, Houston, USA

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  2. William M. McIsaac

    1. Texas Research Institute of Mental Sciences, Texas Medical Center, Houston, USA

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    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Advances in Behavioral Biology (ABBI, volume 1)

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Table of contents (23 papers)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Enzymes: Implications in Mental Disease

    1. Introduction

      • A. Horita
      Pages 1-2

    2. Multiple Forms of Monoamine Oxidase in Developing Tissues: The Implications for Mental Disorder

      • Jean-Hung C. Shih, Samuel Eiduson
      Pages 3-20

    3. Regulation of Catecholamine Biosynthesis: Tyrosine Hydroxylase and Dihydropteridine Reductase

      • José M. Musacchio
      Pages 21-35

    4. Behavioral, Metabolic, and Enzymatic Studies of a Brain Indoleethylamine N-Methylating System

      • Arnold J. Mandell, Bruce Buckingham, David Segal
      Pages 37-60

    5. Transmethylation Processes in Schizophrenia

      • F. Antun, D. Eccleston, J. R. Smythies
      Pages 61-71

  4. Biological Aspects of Affective Disorders

    1. Biogenic Amines and Affective Disorders

      • Alec Coppen
      Pages 123-133

    2. Catecholamines and Affective Illness: Studies with L-DOPA and Alpha-Methyl-Para-Tyrosine

      • Elliot S. Gershon, William E. Bunney Jr., Frederick K. Goodwin, Dennis L. Murphy, David L. Dunner, George M. Henry
      Pages 135-161

    3. Relationships between Stress and Brain 5-Hydroxytryptamine and Their Possible Significance in Affective Disorders

      • G. Curzon
      Pages 163-176

    4. Interactions between Adrenocortical Steroid Hormones, Electrolytes, and the Catecholamines

      • James W. Maas
      Pages 177-195

    5. Thyroid-Imipramine Interaction: Clinical Results and Basic Mechanism

      • Arthur J. Prange Jr., Ian C. Wilson, Angelina E. Knox, Thomas K. McClane, George R. Breese, Billy R. Martin et al.
      Pages 197-213

    6. Effects of Tricyclic Antidepressants on Norepinephrine Metabolism: Basic and Clinical Studies

      • Joseph J. Schildkraut, Paul R. Draskoczy, Elliot S. Gershon, Peter Reich, Edwin L. Grab
      Pages 215-236

  5. Brain Amines and Affective Disorders

    1. Overview

      • Seymour Kety
      Pages 237-244

    2. Discussion

      • Beng T. Ho, William M. McIsaac
      Pages 245-263

  6. Genetic and Metabolic Factors in Mental Disorders

    1. Heterogeneous Distributions of Schizophrenia

      • George Wilson McBee
      Pages 265-274

    2. Frequency of Genetic Polymorphism: Implications for Mental Disease

      • Charles R. Shaw
      Pages 275-280
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Keywords

About this book

This volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britain presented new material and reviewed current concepts concerning schizophrenia and the affective disorders, with particular reference to the neurochemical basis of the etiology and chemotherapy of these diseases. Although the multiple mechanisms of mental disease are still not fully understood, substantial progress has definitely been made. The greatest contribution has come through the development of new therapeutic agents that not only provide invaluable help to the mentally ill but serve as chemical tools for studying the biological mechanisms associated with the disease state. Studies concerning the proposed catecholamine and indolealkylamine hypotheses for affective disorders and the possible formation of endogenous. toxins in schizophrenia have stimulated significant new research. This book presents new studies of schizophrenia and the affective disorders in one volume. It is our hope that it represents an effective integration of basic biochemical and pharmacological research with current clinical findings and that it will increase understanding of the etiology of mental disease and provide an impetus for the development of more effective therapeutic agents. We thank Drs. Gordon Farrell, Samuel Gershon, A. Horita, Irwin Kopin, and Joseph Schildkraut for their help with the organization of the meeting and for chairing the corresponding sessions.

Editors and Affiliations

  • Texas Research Institute of Mental Sciences, Texas Medical Center, Houston, USA

    Beng T. Ho, William M. McIsaac

Bibliographic Information

  • Book Title: Brain Chemistry and Mental Disease

  • Book Subtitle: Proceedings of a Symposium on Brain Chemistry and Mental Disease held at the Texas Research Institute, Houston, Texas, November 18–20, 1970

  • Editors: Beng T. Ho, William M. McIsaac

  • Series Title: Advances in Behavioral Biology

  • DOI: https://doi.org/10.1007/978-1-4684-3057-8

  • Publisher: Springer New York, NY

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer Science+Business Media New York 1971

  • Softcover ISBN: 978-1-4684-3059-2Published: 15 May 2013

  • eBook ISBN: 978-1-4684-3057-8Published: 13 March 2013

  • Series ISSN: 0099-6246

  • Edition Number: 1

  • Number of Pages: XIII, 411

  • Topics: Neurosciences

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