Tumor Virus-Host Cell Interaction

1. Front Matter

   Pages i-x

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2. Simian Virus 40 and Polyoma Virus

   1. Front Matter

      Pages 1-1

      PDF

   2. Knowledge and Ignorance about the Molecular Biology of Small Oncogenic DNA Containing Viruses

      • R. Dulbecco

      Pages 3-11

   3. Studies of SV40 DNA Replication

      • George C. Fareed, Norman P. Salzman

      Pages 13-19

   4. An Analysis of the Structure of the Replicating Fork During Discontinuous Synthesis of SV40 DNA and the Detection of Gap Circle Intermediates

      • Philip J. Laipis, A. J. Levine

      Pages 21-37

   5. The Repeated Sequences in Serially Passaged SV40 DNA

      • N. Frenkel, S. Rozenblatt, E. Winocour

      Pages 39-58

   6. Some Properties of Superhelical Oligomeric and Integrated SV40 DNA Sequences

      • Gerhard Sauer, Christa Kuhn, Klaus Kammer, Waldemar Waldeck

      Pages 59-67

   7. Simian Virus 40 in Synchronized Monkey Cells: Integration of Viral DNA into the Cell Genome and Timing of Replication

      • Marc Girard, Simone Manteuil, Marc Fiszman, Maria Marx, Gisèle Danglot

      Pages 69-89

   8. Transcription of SV40 in Lytically Infected and Transformed Cells

      • Joe Sambrook, Arlene Jackson, Walter Keller, Brad Ozanne, Phillip A. Sharp, Bill Sugden

      Pages 91-116

   9. The Structural Proteins of SV40 and Polyoma Virus

      • Bernhard Hirt

      Pages 117-125

   10. The Cell Free Translation of Purified Simian Virus 40 Messenger RNA

       • Carol Prives

       Pages 127-139

   11. Studies on Non-Transforming Host Range Mutants of Polyoma Virus

       • Thomas L. Benjamin, Leonard Norkin, Emanuel Goldman

       Pages 141-147

   12. The Properties of a Polyoma Virus Mutant, ts3

       • R. Dulbecco

       Pages 149-151

3. Adenovirus

   1. Front Matter

      Pages 153-153

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   2. Intracellular forms of Adenovirus DNA in Productively Infected Cells: Evidence for Integration of the Viral Genome

      • Walter Doerfler, Harold Burger, Ulla Lundholm, Ute Rensing

      Pages 155-181

   3. The Mechanism of Replication of Adenovirus Type 5 DNA

      • J. S. Sussenbach, P. C. van der Vliet, D. J. Ellens, J. Vlak, H. S. Jansz

      Pages 183-195

   4. The Isolation and Characterization of DNA Binding Proteins Specific for Adenovirus Infected Cells

      • Peter van der Vliet, Arnold J. Levine

      Pages 197-216

   5. Adenovirus DNA: Transcription During Productive Infection, Integration in Transformed Cells, and Replication in Vitro

      • Maurice Green, Tadashi Yamashita, Werner Büttner, Kei Fujinaga, Max Arens, Karl Brackmann et al.

      Pages 217-236

   6. Characterization and Metabolism of Nuclear Viral RNA Synthesized 18 Hours after Infection with Adenovirus 2

      • Michael Brunner, Heschel J. Raskas

      Pages 237-252

4. Oncornavirus, Oncogenic RNA Viruses

   1. Front Matter

      Pages 253-253

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The oncogenic virus can only be studied as a carcinogen when its relation to the host cell in which it resides is understood. The interaction between tumor virus and host cell was the subject of a recent North Atlantic Treaty Organization Advanced Study I~stitute. This volume is the edited proceedings of this study institute. One problem of fundamental importance in understanding malignant transformation is the mechanism by which the oncogenic vector promotes the aberrations in the host cell regulatory appara­ tus resulting in a cancerous cell. It is partly the purpose of this volume to help clarify this problem, and to stimulate the interest of others to continue the research necessary to this end. The meeting from which this volume is compiled took place in the Principality of Monaco with the patronage of Her Serene High­ ness, Princess Grace and was supported principally by a grant from the North Atlantic Treaty Organization. The editor wishes to thank the North Atlantic Treaty Organization, Princess Grace of Monaco, and the Bureau de Tourism Monaco for their generous support. Addi­ tional financial assistance was provided by the Deutsches Studium Gesellschaft and I would like to thank Prof. Klaus Munk, Deutsches Krebsforschungszentrum, for his help in obtaining this aid. I would also like to thank the Verwaltung of the Deutsches Krebsfor­ schungszentrum for their administrative help.

• antigen
• cancer
• cell
• infection
• leukemia
• molecular biology
• organizations
• proteins
• research
• resistance
• tumor
• virus

• Virus Institute, German Cancer Research Institute, Heidelberg, Germany

  Alan Kolber

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