Myelination and Demyelination

1. Front Matter

   Pages i-xii

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2. Introduction and Comments

   1. Introduction and Comments

      • Elizabeth Roboz Einstein

      Pages 1-16

3. Myelination

   1. Front Matter

      Pages 17-17

      PDF

   2. Biochemistry

      1. Biosynthesis of Myelin and Neurotoxic Factors in the Serum of Multiple Sclerosis Patients

         • A. N. Davison, M. I. Sabri

         Pages 19-25

      2. Lipid and Fatty Acid Composition of Human Cerebral Myelin during Development

         • Lars Svennerholm, Marie T. Vanier

         Pages 27-41

      3. Enzymic Studies on Glial and Neuronal Cells during Myelination

         • Helmut Woelk, Rosemarie Jahrreiss

         Pages 43-53

      4. Regional Developmental and Fractional Studies on Myelin and Other Carbonic Anhydrases in Rat CNS

         • Victor Sapirstein, Michael Trachtenberg, Marjorie B. Lees, Omanand Koul

         Pages 55-69

      5. Studies of Isolated, Maintained Oligodendroglia: Biochemistry, Metabolism, and <u>In Vitro</u> Myelin Synthesis

         • Shirley E. Poduslo

         Pages 71-94

      6. Studies on Myelin Proteins in Human Peripheral Nerve

         • Keiichi Uyemura, Masaru Suzuki, Kunio Kitamura

         Pages 95-115

      7. Protein Heterogeneity in Rat CNS Myelin Subfractions

         • T. V. Waehneldt

         Pages 117-133

      8. The Preparation and Analysis of Myelin from Small Quantities of Central Nervous Tissue: Regional Studies of the Quaking Mouse

         • G. E. Fagg, T. V. Waehneldt, V. Neuhoff

         Pages 135-145

      9. Studies on the Action of Myelin Basic Protein (MBP) in Rat Brain

         • C. G. Honegger, W. Bucher, H. P. von Hahn

         Pages 147-157

      10. <u>In Vivo</u> Incorporation of ³²P into Myelin Basic Protein from Normal and Quaking Mice

          • Jean-Marie Matthieu, Adrien D. Kuffer

          Pages 159-170

      11. Abnormal Myelin Maturation <u>In Vitro</u>: the Role of Cerebrosides

          • Keith Bradbury

          Pages 171-178

      12. Retardation of Brain Myelination by Malnourishment and Feeding Low Protein Irradiated Diet in Rats

          • Mohammad Habibulla, Hema Krishnan

          Pages 179-186

   3. Molecular Organization

      1. The Molecular Architecture of Myelin: Identification of the External Surface Membrane Components

         • Joseph F. Poduslo

         Pages 189-205

      2. Conformation of Myelin Basic Protein and Its Role in Myelin Formation

         • B. E. Chapman, L. T. Littlemore, W. J. Moore

         Pages 207-220

      3. Cross-Linking of Lipid Bilayers by Central Nervous System Myelin Basic Protein: Aggregation of Free and Vesicle-Bound Protein

         • Ross Smith

         Pages 221-234

      4. Molecular Organisation in Central Nerve Myelin

         • A. J. Crang, M. G. Rumsby

         Pages 235-248

      5. Covalent Probe Investigations with Isolated Central Nerve Myelin Preparations

         • A. J. Crang, Jacqueline Grainger, M. G. Rumsby

         Pages 249-261

A satellite symposium entitled "Myelination and Demyelination: Recent Chemical Advances" was held in Helsinki from August 29 to 31, 1977, after the Sixth International Meeting of the International Society for Neurochemistry (ISN) in Copenhagen. Myelin is a nervous tissue structure that is most suitable as a subject of biochemical investigation. It is easy to isolate in a highly purified form, is rather stable even after death, and is af­ fected by a variety of neurological and other diseases. Its lesions are particularly important in the study of multiple sclerosis, a disease which is relatively prevalent in Finland and has therefore been of interest to a great many Finnish scientists. The first half of this book is concerned with the biochemical composition and molecular organization of myelin, the second half with the experimental and clinical aspects of demyelination. The comments given after each of the presentations at the symposium were not recorded as such, but each author was requested to modify his or her paper accordingly. The editing and publication of this book would not have been possible without the excellent efforts and co-operation of my wife, Mrs. L.-M. Palo, acting as general secretary and later as editorial secretary of the symposium. As Organizing Committee Chairman, I would also like to thank the members of the Committee: Dr. M. Haltia, Dr. E. Kivalo, Dr. T. Kosunen, Dr. M. Panelius, and especially Dr.

• biochemistry
• brain
• experiment
• multiple sclerosis
• muscle
• myelin
• nervous system
• neurochemistry
• organization

• University of Helsinki, Helsinki, Finland

  Jorma Palo

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