Pharmacology and Pharmacokinetics

1. Front Matter

   Pages i-xii

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2. Introduction

   • G. Segre

   Pages 1-1

3. Classical Pharmacokinetics to the Frontier

   • Edward R. Garrett

   Pages 3-25

4. A Modern View of Pharmacokinetics

   • John G. Wagner

   Pages 27-68

5. Translation of Pharmacokinetics to Clinical Medicine

   • L. Dettli

   Pages 69-85

6. Effect of Route of Administration on Drug Disposition

   • S. Riegelman, M. Rowland

   Pages 87-103

7. Interspecies Scaling

   • R. T. Williams

   Pages 105-115

8. Animal Scale-Up

   • Robert L. Dedrick

   Pages 117-145

9. Drug Metabolism in Normal and Disease States

   • A. H. Conney, B. Craver, R. Kuntzman, E. J. Pantuck

   Pages 147-162

10. Drug Action: Target Tissue, Dose-Response Relationships, and Receptors

    • E. J. Ariëns, A. M. Simonis

    Pages 163-189

11. Pharmacokinetics and Pharmacodynamics of Acetazolamide in Relation to its Use in the Treatment of Glaucoma

    • Per J. Wistrand

    Pages 191-194

12. The Role of the Lungs in the Metabolism of Vasoactive Substances

    • John R. Vane

    Pages 195-207

13. The Importance of Tissue Distribution in Pharmacokinetics

    • James R. Gillette

    Pages 209-231

14. Physiological and Physical Factors Governing the Initial Stages of Drug Distribution

    • Seymour S. Kety

    Pages 233-240

15. Target Organ Modification in Pharmacology: Reversible Osmotic Opening of the Blood-Brain Barrier by Opening of Tight Junctions

    • Stanley I. Rapoport

    Pages 241-251

16. Pharmacogenetics: Single Gene Effects

    • Bert N. La Du

    Pages 253-260

17. Application of Pharmacokinetic Principles to the Elucidation of Polygenically Controlled Differences in Drug Response

    • Elliot S. Vesell

    Pages 261-280

18. Immediate Immunologic Reactions: Noncytolytic Mediator Release and Cytolytic Cell Destruction

    • Edward J. Goetzl, Shaun Ruddy, Daniel J. Stechschulte, K. Frank Austen

    Pages 281-296

19. Pharmacokinetic Studies with Amphetamines: Relationship to Neuropsychiatric Disorders

    • Lars-M. Gunne, Erik Änggård

    Pages 297-313

20. A Pharmacokinetic Approach to the Treatment of Depression

    • Folke Sjöqvist

    Pages 315-320

This collection of papers by leading pharmacokineticists and pharmacolo­ gists is the proceedings of a conference held at the John E. · Fogarty International Center for Advanced Study in the Health Sciences, National Institutes of Health, October 30 to November 1, 1972. As part of its advanced study program, the Center conducts workshops, seminars, and conferences on topics related to the biomedical interests of the Scholars-in­ Residence. Professor Torsten Teorell came to the Center in 1970 as one of the first Scholars. In 1971 and 1972, he spent several months at the Center devoting his attention to contemporary problems in the application of pharmacoki­ netics to experimental and clinical pharmacology. As one of the founders of pharmacokinetics, Professor Teorell has made many contributions to the field since he first presented a formal multicompartment model for the analysis of drug action and drug metabolism in 1937 (Teorell, 1937). Since the appearance of his original paper, pharmacodynamics, or pharmacoki­ netics, has become increasingly important as a tool for the study of drug action in patients. The translation of experimental pharmacological findings into therapeutic regimens is today increasingly dependent on ade qua te models of drug action. The purpose of the conference, of which this book is the proceedings, was to discuss contemporary findings in this important biomedical research field. The conference program was designed by Professor Teorell with the help of a small committee which included Drs. Edward R.

• drug
• kinetics
• metabolism
• pharmacodynamics
• pharmacokinetics
• research

• Institute of Physiology and Medical Biophysics, University of Uppsala, Uppsala, Sweden

  Torsten Teorell

• Fogarty International Center, National Institutes of Health, Bethesda, USA

  Torsten Teorell

• Biomedical Engineering and Instrumentation Branch Division of Research Services, National Institutes of Health, Bethesda, USA

  Robert L. Dedrick

• Laboratory of Nutrition and Endocrinology, National Institute of Arthritis, Metabolism, and Digestive Diseases National Institutes of Health, Bethesda, USA

  Peter G. Condliffe

Policies and ethics