Cell and Molecular Biology of the Uterus

1. Front Matter

   Pages i-viii

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2. Cellular and Tissue Mechanisms of Primate Uterine Endometrial Renewal: An Hypothesis

   • Helen A. Padykula

   Pages 1-12

3. Estrogen Receptors as Nuclear Proteins

   • Jack Gorski, Jeffrey C. Hansen, Wade V. Welshons

   Pages 13-29

4. Monoclonal Antibodies Against Putative Nuclear Acceptor Sites of the Avian Oviduct Progesterone Receptor

   • Thomas C. Spelsberg, Amy Goldberger, Michael Horton, Bruce Littlefield, Barbara Gosse, Kay Rasmussen

   Pages 31-48

5. Progesterone-Modulation of Estrogen Action: Rapid Down Regulation of Nuclear Acceptor Sites for the Estrogen Receptor

   • Wendell W. Leavitt, Andrea D. Cobb, Akihiro Takeda

   Pages 49-78

6. The Rabbit Progesterone Receptor and Uteroglobin Gene Expression

   • D. W. Bullock, D. J. Lamb, V. C. Rider, P. E. Kima

   Pages 79-97

7. Interactions Between Estrogen and EGF in Uterine Growth and Function

   • G. M. Stancel, R. M. Gardner, J. L. Kirkland, T. H. Lin, R. B. Lingham, D. S. Loose-Mitchell et al.

   Pages 99-118

8. Hormonal Regulation of Rat Uterine Secretory Protein Synthesis

   • C. Richard Lyttle, Carol Wheeler, Barry S. Komm

   Pages 119-136

9. Hormonal Control and Function of Secretory Proteins

   • R. Michael Roberts, Mary K. Murray, Michael G. Burke, Catherine M. Ketcham, Fuller W. Bazer

   Pages 137-150

10. Analysis of Proteins Secreted by the Human Endometrium In Vivo and In Vitro

    • David T. MacLaughlin, George S. Richardson, Nanette F. Santoro, Anne A. Hargraves, Hans H. Bauer

    Pages 151-165

11. Progestin-Dependent Human Endometrial Protein: A Marker for Monitoring Human Endometrial Function

    • Sharad G. Joshi

    Pages 167-186

12. Decidual Cell Function: Evidence for A Role in the Regulation of Serum CBG and A 60Kda Protein During Early Pregnancy in the Hamster

    • Wendell W. Leavitt, Sabine Rundle, Kevin Thompson, Kyle W. Selcer, Gary O. Gray

    Pages 187-205

13. Implantation Associated Changes in Uterine Secreted Proteins

    • Harry M. Weitlauf

    Pages 207-220

14. The Role of Ovine Conceptus Secretory Proteins in the Establishment of Pregnancy

    • Fuller W. Bazer, J. L. Vallet, C. J. Ashworth, R. V. Anthony, R. M. Roberts

    Pages 221-235

15. Perspectives for Future Research on the Uterus

    • Koji Yoshinaga

    Pages 237-240

16. Back Matter

    Pages 241-246

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The papers in this volume were presented at the Symposium on Cell Biology of the Uterus held December 12, 1986, on the NIH campus, Bethesda, MD. This was the first of a series of meetings that will be held in con­ junction with the annual meeting of the American Society for Cell Biology. The uterus is now recognized as an extremely complex organ whose nor­ mal function is orchestrated by a delicate procession of cellular and molecular events that investigators are beginning to unravel for the first time. Powerful new analytical methods and the tools of molecular biology are now providing exciting breakthroughs in our basic understanding of uterine structure and function. Thus, the program of this meeting was or­ ganized to cover recent developments in uterine cell biology including the mechanism of hormone action, control of gene expression by nuclear acceptor sites and nuclear receptors, role of growth factors, endometrial cell kine­ tics during the menstrual cycle, regulation of specific protein synthesis and secretion, decidual cell function, and the role of early pregnancy pro­ teins. The material presented in this volume is concerned not only with how hormones and growth factors prepare the endometrium for implantation of the blastocyst, but it also details the recent characterization and identification of specific marker proteins secreted in response to hormone action and early pregnancy.

• biology
• cell biology
• development
• gene expression
• molecular biology
• protein

• Texas Tech University Health Sciences Center, Lubbock, USA

  Wendell W. Leavitt

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